Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147134 | 0.92 | LMNA (0.45) | TP53CREBBPHDAC1HDAC6LMNA | |
| SCHEMBL5145428 | 0.88 | DOT1L (0.45) | TP53CREBBPS1PR1HDAC1HDAC6 | |
| SCHEMBL5147135 | 0.86 | HDAC1 (0.43) | TP53CREBBPHDAC1HDAC6LMNA | |
| SCHEMBL5147107 | 0.85 | CYP2D6 (0.48) | HDAC1HDAC6LMNAMAPTTSHR | |
| SCHEMBL5147078 | 0.77 | HDAC1 (0.48) | TP53CREBBPHDAC1HDAC6LMNA | |
| SCHEMBL5148480 | 0.77 | PTGS1 (0.44) | HDAC1HDAC6LMNAPTGS1PTGS2 | |
| SCHEMBL14422443 | 0.76 | TP53 (0.41) | TP53CREBBPHDAC1HDAC6LMNA | |
| SCHEMBL4771960 | 0.76 | CYP3A4 (0.43) | TP53CREBBPHDAC1HDAC6PTGS1 | |
| SCHEMBL5145359 | 0.74 | GRM4 (0.35) | TP53LMNAGRM4MAOBKDM4E | |
| SCHEMBL5145355 | 0.74 | GRM4 (0.35) | TP53LMNAGRM4MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | claimed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070185184-A1 | Carbazole derivatives | SERENEX, INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2007035620-A2 | CARBAZOLE DERIVATIVES | SERENEX, INC. (US) | 2007-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185184-A1 | Carbazole derivatives | CCNI, MKI67, CCNB3 | TP53 111/4885CREBBP 2874/4885S1PR1 858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.