Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096386 | 0.83 | LMNA (0.66) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL377908 | 0.83 | LMNA (0.66) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL10602038 | 0.81 | LMNA (0.62) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL11459127 | 0.81 | LMNA (0.71) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| Ethotoin SCHEMBL34301 | 0.79 | LMNA (1.00) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| Ethotoin SCHEMBL34302 | 0.79 | LMNA (1.00) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL22265963 | 0.78 | LMNA (0.68) | LMNAADORA3TSHRALDH1A1MEN1 | |
| SCHEMBL20459536 | 0.77 | LMNA (0.66) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL7202789 | 0.77 | LMNA (0.66) | LMNAADORA3SMN1; SMN2EP300CREBBP | |
| SCHEMBL17622943 | 0.77 | LMNA (0.66) | LMNAADORA3SMN1; SMN2EP300CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |
| EP-0116825-A1 | New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use | Pierrel S.p.A. (IT) | 1984-08-29 | — | — | EP | disclosed |