Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 8/20 | 0.51 |
| ▸ | USP7 | Q93009 | 3/20 | 0.39 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 4/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.31 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | EGFR | P00533 | 3/20 | 0.31 |
| ▸ | HCK | P08631 | 3/20 | 0.31 |
| ▸ | SRC | P12931 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.31 |
| ▸ | PRKDC | P78527 | 3/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149248 | 1.00 | USP8 (0.51) | USP8USP7USP47ADORA2AMYC | |
| SCHEMBL5152779 | 0.93 | USP8 (0.46) | USP8USP7USP47MYCWDR5 | |
| SCHEMBL5147962 | 0.85 | USP8 (0.46) | USP8USP7USP47ADORA2AMTOR | |
| SCHEMBL5147922 | 0.85 | USP8 (0.46) | USP8USP7USP47ADORA2AMTOR | |
| SCHEMBL5147996 | 0.84 | ADORA2A (0.36) | USP8ADORA2AIKBKBFGFR1FGFR2 | |
| SCHEMBL5152934 | 0.82 | ADORA2A (0.36) | ADORA2AATR | |
| SCHEMBL5150681 | 0.81 | USP8 (0.34) | USP8USP7USP47 | |
| SCHEMBL5150678 | 0.81 | USP8 (0.34) | USP8USP7USP47 | |
| SCHEMBL5152670 | 0.80 | ADORA2A (0.38) | ADORA2AMYCWDR5ATRFGFR1 | |
| SCHEMBL5151091 | 0.79 | ADORA2A (0.43) | USP8ADORA2AMTORPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265120-B2 | Pyrazine derivatives and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2007-09-04 | — | — | US | disclosed |
| CN-1938296-A | Pyrazine derivatives and pharmaceutical use thereof as adenosine antagonists | ASTELLAS PHARMA INC (JP) | 2007-03-28 | — | — | CN | disclosed |
| EP-1737841-A1 | PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF AS ADENOSINE ANTAGONISTS | Astellas Pharma Inc. (JP) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005095384-A1 | PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF AS ADENOSINE ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222159-A1 | Pyrazine derivatives and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222159-A1 | Pyrazine derivatives and pharmaceutical use thereof | ADORA2A, HTR5A, ADORA1 | USP8 4814/4885USP7 4772/4885USP47 4614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.