Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14483974 | 0.86 | ABCG2 (0.56) | MAPTHDAC1TDP1CYP3A4 | |
| SCHEMBL5901817 | 0.85 | RXFP1 (0.50) | KDRFLT1SCN8ASCN10ARXFP1 | |
| SCHEMBL4980248 | 0.82 | KDR (0.74) | KDRFLT1RXFP1KITABL1 | |
| SCHEMBL5900863 | 0.80 | RXFP1 (0.53) | KDRFLT1SCN8ASCN10ARXFP1 | |
| SCHEMBL1037818 | 0.80 | RXFP1 (0.75) | KDRFLT1RXFP1KITABL1 | |
| SCHEMBL5900542 | 0.79 | RXFP1 (0.52) | KDRFLT1RXFP1KITABL1 | |
| SCHEMBL5900615 | 0.79 | KDR (0.54) | KDRFLT1RXFP1MAPTKIT | |
| SCHEMBL5900801 | 0.78 | KDM4E (0.52) | KDRFLT1SCN8ASCN10ARXFP1 | |
| SCHEMBL5151475 | 0.77 | ADRA1A (0.54) | MAPT | |
| SCHEMBL5900655 | 0.76 | RXFP1 (0.48) | KDRFLT1RXFP1KITABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135489-A1 | Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridones | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135489-A1 | Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridones | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-06-14 | — | — | US | disclosed |
| US-20070135489-A1 | Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridones | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-06-14 | — | — | US | disclosed |
| US-7202260-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | SCHERING AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202260-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | SCHERING AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202260-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | SCHERING AG (DE) | 2007-04-10 | — | — | US | disclosed |
| CN-1805936-A | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | SCHERING AG (DE) | 2006-07-19 | — | — | CN | disclosed |
| US-20050049281-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049281-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones | FLT4, KDR, FLT1 | KDR 2/4885FLT1 3/4885SCN8A 4607/4885 |
| US-20070135489-A1 | Vegfr-2 and vegfr-3 inhibitory anthranilamide pyridones | FLT4, KDR, FLT1 | KDR 2/4885FLT1 3/4885SCN8A 4607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.