Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.45 |
| ▸ | CASP1 | P29466 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | CASP7 | P55210 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153106 | 0.78 | SMN1; SMN2 (0.44) | ALDH1A1HSD17B10CASP1KDM4ECASP7 | |
| SCHEMBL5150142 | 0.78 | ALDH1A1 (0.52) | ALDH1A1PDE4BPDE7APDE2APDE5A | |
| SCHEMBL5150370 | 0.77 | PDE4B (0.52) | ALDH1A1PDE4BPDE7APDE2APDE5A | |
| SCHEMBL5153869 | 0.73 | ALDH1A1 (0.45) | ALDH1A1PDE4BPDE7APDE2APDE5A | |
| SCHEMBL5153850 | 0.73 | ALDH1A1 (0.45) | ALDH1A1PDE4BPDE7APDE2APDE5A | |
| SCHEMBL5155804 | 0.70 | CYP1A2 (0.52) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL5152091 | 0.70 | CYP1A2 (0.52) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL5336593 | 0.68 | CYP1A2 (0.50) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL5153474 | 0.64 | TP53 (0.45) | ALDH1A1HSD17B10CASP1CASP7HPGD | |
| SCHEMBL8241131 | 0.64 | CYP1A2 (0.44) | ALDH1A1HSD17B10CASP1KDM4ECASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225304-A1 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| WO-2007030438-A2 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225304-A1 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | TPMT, ADORA2A, ENTPD5 | ALDH1A1 705/4885PDE4B 701/4885PDE7A 517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.