Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2039588 | 0.87 | CYP19A1 (0.54) | CYP19A1SMN1; SMN2ALDH1A1GPR35TP53 | |
| SCHEMBL8128575 | 0.84 | SMN1; SMN2 (0.46) | CYP19A1SMN1; SMN2ALDH1A1GPR35TP53 | |
| SCHEMBL11835883 | 0.84 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL31081103 | 0.83 | HTT (0.60) | CYP19A1SMN1; SMN2ALDH1A1HPGDMAPK1 | |
| SCHEMBL22954121 | 0.83 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1GPR35TP53HPGD | |
| SCHEMBL3820703 | 0.83 | HTT (0.60) | CYP19A1SMN1; SMN2ALDH1A1HPGDMAPK1 | |
| SCHEMBL9699062 | 0.81 | CYP19A1 (0.58) | CYP19A1SMN1; SMN2ALDH1A1TSHRHTT | |
| SCHEMBL3295088 | 0.81 | HTT (0.67) | CYP19A1SMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL221924 | 0.81 | HTT (0.66) | SMN1; SMN2ALDH1A1GPR35TP53HPGD | |
| SCHEMBL31493924 | 0.81 | HTT (0.66) | SMN1; SMN2ALDH1A1GPR35TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007071840-A2 | COMPOUNDS BASED ON FOUR AROMATIC RINGS, PREPARATION AND USES THEREOF | CEREP (FR) | 2007-06-28 | — | — | WO | disclosed |
| EP-1135360-B1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PF MEDICAMENT (FR) | 2004-03-31 | — | — | EP | disclosed |
| US-6350913-B1 | AROMATIC AMINE COMPOUNDS | PIERRE FABRE MEDICAMENT (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1135360-A1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000032557-A1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2000-06-08 | — | — | WO | disclosed |