Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153465 | 0.85 | ADORA2A (0.48) | ADORA2AADORA1TP53ALDH1A1MEN1 | |
| SCHEMBL8241181 | 0.84 | ADORA2A (0.47) | ADORA2AADORA1ALDH1A1MEN1USP2 | |
| SCHEMBL5152247 | 0.82 | USP2 (0.48) | ADORA2AADORA1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL5153106 | 0.79 | SMN1; SMN2 (0.44) | ADORA2AADORA1SMN1; SMN2TP53POLB | |
| SCHEMBL5150142 | 0.78 | ALDH1A1 (0.52) | ADORA2AADORA1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL4507899 | 0.78 | ADORA2A (0.53) | ADORA2AADORA1ALDH1A1USP2CYP1A2 | |
| SCHEMBL5332245 | 0.75 | ADORA2A (0.69) | ADORA2AADORA1 | |
| SCHEMBL4525961 | 0.74 | ADORA2A (0.81) | ADORA2AADORA1 | |
| SCHEMBL13966183 | 0.74 | ADORA2A (0.67) | ADORA2AADORA1 | |
| SCHEMBL13966117 | 0.73 | ADORA2A (0.66) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225304-A1 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070225304-A1 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| WO-2007030438-A2 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225304-A1 | AMINOPURINE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | TPMT, ADORA2A, ENTPD5 | ADORA2A 2/4885ADORA1 4/4885SMN1; SMN2 431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.