Ethylenediamine

Ethylenediamine

SCHEMBL515314

C=CC(=O)N(C)C.NCCN

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.35
ALDH1A1 P00352 6/20 0.35
FGFR4 P22455 1/20 0.35
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
HPGD P15428 1/20 0.31
ZDHHC20 Q5W0Z9 1/20 0.31
ZDHHC2 Q9UIJ5 1/20 0.31
LMNA P02545 1/20 0.30
TP53 P04637 2/20 0.30
HIF1A Q16665 2/20 0.30
CYP3A4 P08684 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15015 0.87
SCHEMBL28332742 0.85 CYP2C19 (0.43) ALDH1A1ZDHHC20ZDHHC2LMNATP53
Urea SCHEMBL28731521 0.84 ALDH1A1 (0.45) TSHRALDH1A1FGFR4CHRNB2CHRNB4
Propane SCHEMBL10501126 0.84 ALDH1A1 (0.43) TSHRALDH1A1FGFR4CHRNB2CHRNB4
Hydrochloric Acid SCHEMBL8593624 0.84
Ethane SCHEMBL10637100 0.84
Ammonia Solution, Strong SCHEMBL16774831 0.84
SCHEMBL253241 0.84
Methane SCHEMBL10717295 0.84
Bromide SCHEMBL31360976 0.84 ALDH1A1 (0.42) TSHRALDH1A1FGFR4CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 435 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11364695-B2 Silicone hydrogel lenses with water-rich surfaces ALCON INC. (CH) 2022-06-21 US claimed
US-11235083-B2 Composite hydrogel and metal silicate wound healing material MLK BIOSCIENCE CO., LTD. (TW) 2022-02-01 US claimed
CN-108721677-B Composite material 广西美丽肤医疗器械有限公司 2021-11-19 CN claimed
EP-3268804-B1 MESH SIZE CONTROL OF LUBRICATION IN GEMINI HYDROGELS UNIV FLORIDA (US) 2020-11-04 EP claimed
US-20200339836-A1 SILICONE HYDROGEL LENSES WITH WATER-RICH SURFACES ALCON INC. (CH) 2020-10-29 US claimed
US-10795057-B2 Composition for manufacturing contact lenses BENQ MATERIALS CORPORATION (TW) 2020-10-06 US claimed
US-10781340-B2 Silicone hydrogel lenses with water-rich surfaces ALCON INC. (CH) 2020-09-22 US claimed
US-10723842-B2 Mesh size control of lubrication in gemini hydrogels UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2020-07-28 US claimed
US-20200114039-A1 Composite Material WANG, WAN-TING (TW) 2020-04-16 US claimed
EP-3613444-A1 COMPOSITE MATERIAL Wang, Wan-Ting (TW) 2020-02-26 EP claimed
EP-2513711-A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS Novartis AG (CH) 2012-10-24 EP claimed
EP-2510051-A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES Novartis AG (CH) 2012-10-17 EP claimed
WO-2011075377-A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011071790-A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES NOVARTIS AG (CH) 2011-06-16 WO claimed
US-20110140292-A1 METHODS FOR MAKING SILICONE HYDROGEL LENSES FROM WATER-BASED LENS FORMULATIONS ALCON INC. (CH) 2011-06-16 US claimed
US-20110133350-A1 METHODS FOR INCREASING THE ION PERMEABILITY OF CONTACT LENSES ALCON INC. (CH) 2011-06-09 US claimed
JP-2010501366-A 2010-01-21 JP claimed
EP-2038683-A2 PROCESS FOR MAKING OPHTHALMIC LENSES Johnson and Johnson Vision Care, Inc. (US) 2009-03-25 EP claimed
WO-2008005229-A2 PROCESS FOR MAKING OPHTHALMIC LENSES JOHNSON & JOHNSON VISION CARE, INC. (US) 2008-01-10 WO claimed
US-20070222095-A1 PROCESS FOR MAKING OPHTHALMIC LENSES JOHNSON & JOHNSON VISION CARE, INC. 2007-09-27 US claimed