Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958264 | 0.95 | HSD17B10 (0.44) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL7572887 | 0.93 | HSD17B10 (0.41) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL7571534 | 0.93 | HSD17B10 (0.41) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL7722134 | 0.93 | HSD17B10 (0.41) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL8958281 | 0.93 | HSD17B10 (0.43) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL6843066 | 0.92 | HSD17B10 (0.49) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL8958670 | 0.91 | HSD17B10 (0.41) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| Water SCHEMBL5058850 | 0.90 | HSD17B10 (0.47) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL9764214 | 0.87 | KDM4E (0.41) | HSD17B10KDM4ECYP1A2CYP3A4TSHR | |
| SCHEMBL9184214 | 0.87 | GCGR (0.39) | HSD17B10KDM4ECYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984281-B1 | A homogeneous assay for determining analyte | DADE BEHRING MARBURG GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |
| EP-1418430-A2 | A homogeneous assay for determining analyte | Dade Behring Marburg GmbH (DE) | 2004-05-12 | — | — | EP | disclosed |
| EP-0984282-B1 | Particles having an incorporated composition comprising a chemiluminescent compound | DADE BEHRING MARBURG GMBH (DE) | 2003-07-30 | — | — | EP | disclosed |
| EP-0730738-B1 | METAL CHELATE CONTAINING COMPOSITIONS FOR USE IN CHEMILUMINESCENT ASSAYS | DADE BEHRING MARBURG GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| EP-0515194-B1 | Assay methods utilizing induced luminescence | DADE BEHRING MARBURG GMBH (DE) | 2001-10-31 | — | — | EP | disclosed |
| EP-1091211-A1 | Metal chelate containing compositions for use in chemiluminescent assays | Dade Behring Marburg GmbH (DE) | 2001-04-11 | — | — | EP | disclosed |
| EP-0984281-A2 | A homogeneous assay for determining analyte | Dade Behring Marburg GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0984282-A2 | Particles having an incorporated composition comprising a chemiluminescent compound | Dade Behring Marburg GmbH (DE) | 2000-03-08 | — | — | EP | disclosed |
| EP-0730738-A1 | METAL CHELATE CONTAINING COMPOSITIONS FOR USE IN CHEMILUMINESCENT ASSAYS | BEHRINGWERKE AG (DE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014928-A1 | METAL CHELATE CONTAINING COMPOSITIONS FOR USE IN CHEMILUMINESCENT ASSAYS | BEHRINGWERKE AG (DE) | 1995-06-01 | — | — | WO | disclosed |
| EP-0515194-A2 | Assay methods utilizing induced luminescence | BEHRINGWERKE Aktiengesellschaft (DE) | 1992-11-25 | — | — | EP | disclosed |