Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 6/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.69 |
| ▸ | CASP7 | P55210 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.69 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | MDM4 | O15151 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667888 | 1.00 | VDR (0.69) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL3130073 | 0.91 | GPBAR1 (0.57) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL7079943 | 0.90 | GPBAR1 (0.56) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL17501642 | 0.90 | GPBAR1 (0.73) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL15539189 | 0.89 | GPBAR1 (0.71) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL7528741 | 0.87 | GRIN2A (0.52) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL1490581 | 0.87 | GPBAR1 (0.55) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL6879512 | 0.87 | GPBAR1 (0.55) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL29130871 | 0.86 | GPBAR1 (0.77) | VDRGPBAR1CASP7HSD17B10TDP1 | |
| SCHEMBL28932414 | 0.86 | GPBAR1 (0.77) | VDRGPBAR1CASP7HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110612448-B | Method for screening for xanthomatosis of brain tendons using ratio of bile alcohol glucuronide and metabolite | 阿姆斯特丹大学学术医学中心 | 2023-06-13 | — | — | CN | claimed |
| CN-110612448-A | Method for screening brain tendon xanthomatosis using ratio of bile alcohol glucuronide to metabolite | 阿姆斯特丹大学学术医学中心 | 2019-12-24 | — | — | CN | claimed |
| US-4486532-A | IMMOBILIZATION OF FUMARASE-PRODUCING MICROORGANISM | TNANBE SEIYAKU CO., LTD. (JP) | 1984-12-04 | — | — | US | claimed |
| CN-108430514-B | Compositions and methods for treating peroxisome disorders and leukodystrophies | 约翰霍普金斯大学 | 2023-11-03 | — | — | CN | disclosed |
| CN-110612448-B | Method for screening for xanthomatosis of brain tendons using ratio of bile alcohol glucuronide and metabolite | 阿姆斯特丹大学学术医学中心 | 2023-06-13 | — | — | CN | disclosed |
| CN-110612448-A | Method for screening brain tendon xanthomatosis using ratio of bile alcohol glucuronide to metabolite | 阿姆斯特丹大学学术医学中心 | 2019-12-24 | — | — | CN | disclosed |
| WO-2019055268-A2 | DRUG DELIVERY SYSTEM | BARANOWITZ STEVEN (US) | 2019-03-21 | — | — | WO | disclosed |
| EP-3387433-A1 | BILE ACID BIOMARKERS FOR NIEMANN-PICK DISEASES, METHODS AND USES THEREFOR | Washington University (US) | 2018-10-17 | — | — | EP | disclosed |
| WO-2016069759-A1 | BILE ACID BIOMARKERS FOR NIEMANN-PICK DISEASES, METHODS AND USES THEREFOR | WASHINGTON UNIVERSITY (US) | 2016-05-06 | — | — | WO | disclosed |
| WO-2015175479-A1 | PHARMACEUTICAL COMPOSITION | BARANOWITZ STEVEN (US) | 2015-11-19 | — | — | WO | disclosed |
| EP-1751145-A4 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | CHONG KUN DANG PHARM CORP (KR) | 2007-08-01 | — | — | EP | disclosed |
| EP-1751145-A1 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | Chong Kun Dang Pharmaceutical Corp. (KR) | 2007-02-14 | — | — | EP | disclosed |
| WO-2006033505-A1 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2006-03-30 | — | — | WO | disclosed |
| US-4649155-A | Injectable solutions | HOFFMANN-LA ROCHE INC. (US) | 1987-03-10 | — | — | US | disclosed |
| US-4486532-A | IMMOBILIZATION OF FUMARASE-PRODUCING MICROORGANISM | TNANBE SEIYAKU CO., LTD. (JP) | 1984-12-04 | — | — | US | disclosed |