Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.51 |
| ▸ | MME | P08473 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 5/20 | 0.40 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154520 | 1.00 | ACE (0.51) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL5154165 | 1.00 | ACE (0.51) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL5158143 | 1.00 | ACE (0.51) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL5154587 | 1.00 | ACE (0.51) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL10565078 | 0.93 | ACE (0.49) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL11205197 | 0.93 | ACE (0.49) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL7344268 | 0.93 | ACE (0.49) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL7344257 | 0.93 | ACE (0.49) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL10567702 | 0.89 | ACE (0.53) | ACEMMEALDH1A1CHRM2OPRM1 | |
| SCHEMBL7034916 | 0.87 | MME (0.41) | ACEMMEALDH1A1CHRM2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433164-B1 | — | — | None | — | — | US | disclosed |
| EP-1073673-B1 | OCTAHYDRO-6,10-DIOXO-6H-PYRIDAZINO/1,2-a/ /1,2/DIAZEPIN-1-CARBOXYLIC ACID DERIVATIVES, PREPARATION METHOD AND USE FOR PREPARING THERAPEUTICALLY ACTIVE COMPOUNDS | AVENTIS PHARMA SA (FR) | 2007-01-10 | — | — | EP | disclosed |
| EP-0955310-B1 | New derivatives of (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino /1,2-a/ /1,2/ diazepine-1-carboxylic acid, process for their preparation and use for preparation of pharmaceutical agents | AVENTIS PHARMA SA (FR) | 2004-10-13 | — | — | EP | disclosed |
| US-6433164-B2 | SUBSTITUTED ON RING CARBON #9 BY A PRIMARY AMINE WHICH MAY OR MAY NOT BE PROTECTED; DEHYDROGENATION OF THE OCTOHYDRO DERIVATIVE; DRUGS | AVENTIS PHARMA S.A. (FR) | 2002-08-13 | — | — | US | disclosed |
| US-20010002422-A1 | (3,4,7,8,9,10-hexahydro-6, 10 -6H-pyridazino [1,2-a] [1,2,] diazepine-1-carboxylic-acid derivatives | HOECHST MARION ROUSSEL | 2001-05-31 | — | — | US | disclosed |
| EP-0955310-A1 | New derivatives of (3,4,7,8,9,10)-hexahydro-6,10-dioxo-6H-pyridazino /1,2-a/ /1,2/ diazepine-1-carboxylic acid, process for their preparation and use for preparation of pharmaceutical agents | HOECHST MARION ROUSSEL (FR) | 1999-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010002422-A1 | (3,4,7,8,9,10-hexahydro-6, 10 -6H-pyridazino [1,2-a] [1,2,] diazepine-1-carboxylic-acid derivatives | GRIK1, GRIK2, ATXN2L | ACE 1357/4885MME 4589/4885ALDH1A1 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.