Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.53 |
| ▸ | MME | P08473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158143 | 0.89 | ACE (0.51) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL5154520 | 0.89 | ACE (0.51) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL5154528 | 0.89 | ACE (0.51) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL5154165 | 0.89 | ACE (0.51) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL5154587 | 0.89 | ACE (0.51) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL10561930 | 0.85 | CASP3 (0.39) | ACEMMEHSD17B10ALDH1A1DDB1 | |
| SCHEMBL644661 | 0.84 | ACE (0.49) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6527218 | 0.84 | ACE (0.47) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL10565346 | 0.84 | ACE (0.47) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL7342670 | 0.84 | ACE (0.47) | ACEMMEHSD17B10ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808713-A | Anthypertensive pyridazo [1,2-a][1,2]diazepines | HOFFMAN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| US-4772701-A | Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihypertensives | HOFFMANN-LA ROCHE INC. (US) | 1988-09-20 | — | — | US | disclosed |
| US-4658024-A | Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives | HOFFMANN-LA ROCHE INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4512924-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0094095-A2 | Bicyclic carboxylic acids and their alkyl and aralkyl esters | F. HOFFMANN-LA ROCHE AG (CH) | 1983-11-16 | — | — | EP | disclosed |