Phthalazinone

Phthalazinone

SCHEMBL51553

O=c1[nH]ncc2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 1.00
HSD17B10 Q99714 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
ALDH1A1 P00352 1/20 1.00
PRKCI P41743 1/20 1.00
PDE4B Q07343 1/20 1.00
MAPK1 P28482 1/20 0.59
HSP90AA1 P07900 1/20 0.50
IDO1 P14902 1/20 0.50
CDK2 P24941 1/20 0.50
PRMT5 O14744 1/20 0.44
ABCB1 P08183 1/20 0.44
KDM4E B2RXH2 2/20 0.42
ATM Q13315 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
GAA P10253 1/20 0.42
AR P10275 1/20 0.42
CYP1A2 P05177 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalazinone SCHEMBL11519239 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL11516875 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL2473799 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL9617397 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL11519244 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL2962226 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL11690359 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL11516881 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL4663241 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI
Phthalazinone SCHEMBL28416004 0.98 PARP1 (0.96) PARP1HSD17B10TDP1ALDH1A1PRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7571 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080002-A Phthalazinone compound and preparation method and application thereof 2026-05-26 CN claimed
EP-3504196-B1 PROCESSES FOR PREPARING OLAPARIB SCINOPHARM TAIWAN LTD (TW) 2026-04-08 EP claimed
EP-4722203-A1 3,4-DIHYDROPHTHALAZIN-1(2H)-ONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Academy of Military Medical Sciences (CN) 2026-04-08 EP claimed
EP-4713509-A1 PROTON EXCHANGE MEMBRANE AND CATALYST-COATED PROTON EXCHANGE MEMBRANE UOP LLC (US) 2026-03-25 EP claimed
EP-4709906-A1 COMPOSITE PROTON EXCHANGE MEMBRANE AND CATALYST-COATED COMPOSITE PROTON EXCHANGE MEMBRANE UOP LLC (US) 2026-03-18 EP claimed
US-20260060970-A1 Use of a Therapeutic Agent with Phosphodiesterase-7 Inhibitory Activity for the Treatment and Prevention of Diseases Associated with Chronic Fatigue, Exhaustion and/or Exertional Intolerance MITODICURE GMBH (DE) 2026-03-05 US claimed
US-12553107-B2 Method for catalyst recovery from catalyst-coated membranes UOP LLC (US) 2026-02-17 US claimed
EP-4678638-A1 NEW E3 UBIQUITIN LIGASE LIGAND, PROTEIN DEGRADATION AGENT AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-01-14 EP claimed
EP-4653437-A2 NOVEL HETEROCYCLIC COMPOUNDS Innovo Therapeutics Inc. (KR) 2025-11-26 EP claimed
EP-4642763-A1 CRYSTALLINE FORMS OF NLRP3 INFLAMMASOME INHIBITORS, CHEMICAL PROCESSES AND CHEMICAL COMPOUNDS Astrazeneca AB (SE) 2025-11-05 EP claimed
US-4081279-A Photothermographic materials containing radiation sensitive quinone compounds and nitrobenzylidene dyes EASTMAN KODAK COMPANY (US) 1978-03-28 US claimed
US-4076534-A Heat developable light-sensitive material FUJI PHOTO FILM CO., LTD. (JA) 1978-02-28 US claimed
US-4038083-A NON-PHOTOSENSITIVE SILVER SALT AND A PHTHALAZINONE AGFA-GEVAERT N.V. (BE) 1977-07-26 US claimed
US-4022617-A DIFFUSION EASTMAN KODAK COMPANY (US) 1977-05-10 US claimed
US-4021240-A DIFFUSION, SILVER HALIDE OXIDIZER EASTMAN KODAK COMPANY (US) 1977-05-03 US claimed
US-4013473-A THERMOGRAPHY, SUBSTITUTED PHENOL REDUCING AGENT AGFA-GEVAERT N.V. (BE) 1977-03-22 US claimed
US-3985565-A Photothermographic, composition using a phenolic leuco dye as a reducing agent EASTMAN KODAK COMPANY (US) 1976-10-12 US claimed
US-3960908-A AQUEOUS EMULSIONS CONTAINING SILVER SALT, SALT OF CARBOXYLIC ACID AND SOLVENT FUJI PHOTO FILM CO., LTD. (JA) 1976-06-01 US claimed
US-3933508-A ORGANIC SILVER SALT, SILVER HALIDE, REDUCING AGENT, BINDER FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US claimed
US-3933507-A LIGHT INSENSITIVE SILVER SALT, POLYMETHINE SENSITIZER AGFA-GEVAERT, A.G. (DT) 1976-01-20 US claimed