⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL450009 | 0.71 | — | — | |
| SCHEMBL10914129 | 0.64 | — | — | |
| SCHEMBL8901938 | 0.62 | CHRNB2 (0.30) | — | |
| SCHEMBL10757117 | 0.61 | EPAS1 (0.32) | — | |
| SCHEMBL8603606 | 0.60 | EPAS1 (0.34) | — | |
| SCHEMBL2504646 | 0.60 | — | — | |
| SCHEMBL14244062 | 0.58 | — | — | |
| SCHEMBL5635555 | 0.57 | SRD5A1 (0.30) | — | |
| Bicarbonate SCHEMBL11152407 | 0.57 | EGLN1 (0.31) | — | |
| SCHEMBL56056 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654225-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2007-11-28 | — | — | EP | claimed |
| EP-1654225-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | Amgen, Inc. (US) | 2006-05-10 | — | — | EP | claimed |
| US-20050256161-A1 | Melanin concentrating hormone receptor antagonists | AMGEN INC. | 2005-11-17 | — | — | US | claimed |
| WO-2005019240-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN, INC. (US) | 2005-03-03 | — | — | WO | claimed |
| CN-115677443-B | Method for constructing 1, 4-diketone compound by olefin 1, 2-dicarbonylation | 中国科学院理化技术研究所 | 2024-07-16 | — | — | CN | disclosed |
| WO-2024140933-A1 | CAMPTOTHECIN DERIVATIVE, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD AND USE THEREFOR | 长春金赛药业有限责任公司 | 2024-07-04 | — | — | WO | disclosed |
| WO-2024140824-A1 | PYRIDAZINE NLRP3 INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 长春金赛药业有限责任公司 | 2024-07-04 | — | — | WO | disclosed |
| CN-112805062-B | Imidazo [1,2-b ] pyridazines as Trk inhibitors | 博善人工智能生物科技有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-118119619-A | SIK inhibitor and composition, preparation method and application thereof | 上海美悦生物科技发展有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-118108700-A | Complement factor B inhibitor, pharmaceutical composition, preparation method and application thereof | 诺华股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| WO-2024104452-A1 | MC4R ANTAGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL USE THEREOF | 长春金赛药业有限责任公司 | 2024-05-23 | — | — | WO | disclosed |
| CN-118047744-A | Curcumin heterocoumarin photo-diagnosis and treatment agent compound, and preparation method and application thereof | 中国科学院理化技术研究所 | 2024-05-17 | — | — | CN | disclosed |
| CN-111410661-A | Cap-dependent endonuclease inhibitors and uses thereof | 周雨恬 | 2020-07-14 | — | — | CN | disclosed |
| CN-111417394-A | Benzimidazole derivatives and uses thereof | 安进公司 | 2020-07-14 | — | — | CN | disclosed |
| EP-1654225-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1654225-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | Amgen, Inc. (US) | 2006-05-10 | — | — | EP | disclosed |
| US-20050256161-A1 | Melanin concentrating hormone receptor antagonists | AMGEN INC. | 2005-11-17 | — | — | US | disclosed |
| WO-2005019240-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2000066588-A1 | DIRECT C-14 OXIDATION OF OPIOIDS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH A ND HUMAN SERVICES (US) | 2000-11-09 | — | — | WO | disclosed |
| US-5280034-A | Bis-heterocyclic prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1994-01-18 | — | — | US | disclosed |