Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5155386 | 1.00 | CHRNA7 (0.43) | CHRNA7HTR3ACHRNB4CHRNA3HRH4 | |
| SCHEMBL16382029 | 0.81 | OGA (0.39) | HRH4CYP1A2ALOX15CYP2C19OGA | |
| SCHEMBL20609130 | 0.79 | PSEN1 (0.39) | CHRNA7CHRNA3OGAPSEN1PSEN2 | |
| SCHEMBL20609131 | 0.79 | PSEN1 (0.39) | CHRNA7CHRNA3OGAPSEN1PSEN2 | |
| SCHEMBL20609161 | 0.79 | PSEN1 (0.39) | CHRNA7CHRNA3OGAPSEN1PSEN2 | |
| SCHEMBL23504748 | 0.79 | MAPK3 (0.36) | CHRNA7CHRNA3OGAPSEN1PSEN2 | |
| SCHEMBL18971472 | 0.79 | PSEN1 (0.39) | CHRNA7CHRNA3OGAPSEN1PSEN2 | |
| SCHEMBL83919 | 0.78 | CNR2 (0.42) | HRH4CYP1A2ALOX15CYP2C19OGA | |
| SCHEMBL84512 | 0.78 | CNR2 (0.42) | HRH4CYP1A2ALOX15CYP2C19OGA | |
| SCHEMBL84511 | 0.78 | CNR2 (0.42) | HRH4CYP1A2ALOX15CYP2C19OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | CHRNA7 4295/4885HTR3A 1577/4885CHRNB4 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.