Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.99 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.99 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.99 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.99 |
| ▸ | FPR1 | P21462 | 1/20 | 0.99 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.99 |
| ▸ | GPR183 | P32249 | 1/20 | 0.99 |
| ▸ | APLNR | P35414 | 1/20 | 0.99 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.99 |
| ▸ | GLP1R | P43220 | 1/20 | 0.99 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.99 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.99 |
| ▸ | ADGRF1 | Q5T601 | 1/20 | 0.99 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.99 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.99 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.99 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.99 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.99 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.48 |
| ▸ | F2 | P00734 | 10/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713111 | 1.00 | CHRM2 (0.99) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| SCHEMBL5231688 | 1.00 | CHRM2 (0.99) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| Hydrochloric Acid SCHEMBL2358624 | 0.99 | CHRM2 (1.00) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| Hydrochloric Acid SCHEMBL29419935 | 0.99 | CHRM2 (1.00) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| Fumaric Acid SCHEMBL5148833 | 0.96 | CHRM2 (0.92) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| Fumaric Acid SCHEMBL5148843 | 0.96 | CHRM2 (0.92) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| SCHEMBL13984982 | 0.91 | CHRM2 (0.82) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| SCHEMBL5151119 | 0.90 | CHRM2 (0.81) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| SCHEMBL5230609 | 0.90 | CHRM2 (0.81) | CHRM2CHRM5ADRA2CS1PR1FPR1 | |
| SCHEMBL5154396 | 0.89 | CHRM2 (0.79) | CHRM2CHRM5ADRA2CS1PR1FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373233-B1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-09-05 | — | — | EP | claimed |
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | claimed |
| US-20040116353-A1 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI (FR) | 2004-06-17 | — | — | US | claimed |
| US-20120202744-A1 | DUAL ANTAGONISM OF ENDOTHELIN TYPE A AND BRADYKININ B1 RECEPTORS FOR TREATING PAIN AND PREVENTING CARTILAGE DEGRADATION | MOLDOVAN FLORINA (CA) | 2012-08-09 | — | — | US | disclosed |
| WO-2010031577-A1 | USE OF BRADYKININ B1 RECEPTOR ANTAGONISTS IN INTESTINAL FIBROSIS TREATMENT | JERINI AG (DE) | 2010-03-25 | — | — | WO | disclosed |
| US-20080221039-A1 | Kinin Antagonists For Treating Bladder Dysfunction | JERINI AG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20080221039-A1 | Kinin Antagonists For Treating Bladder Dysfunction | JERINI AG (DE) | 2008-09-11 | — | — | US | disclosed |
| EP-1373233-B1 | DERIVATIVES OF N-(ARYLSULFONYL)BETA-AMINOACIDS COMPRISING A SUBSTITUTED AMINOMETHYL GROUP, THE PREPARATION METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007003411-A2 | KININ ANTAGONISTS FOR TREATING BLADDER DYSFUNCTION | JERINI AG (DE) | 2007-01-11 | — | — | WO | disclosed |
| EP-1741444-A1 | Kinin antagonists for treating bladder dysfunction | Jerini AG (DE) | 2007-01-10 | — | — | EP | disclosed |
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | disclosed |
| US-20040116353-A1 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI (FR) | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221039-A1 | Kinin Antagonists For Treating Bladder Dysfunction | BDKRB2, BDKRB1, F2R | CHRM2 391/4885CHRM5 438/4885ADRA2C 268/4885 |
| US-20120202744-A1 | DUAL ANTAGONISM OF ENDOTHELIN TYPE A AND BRADYKININ B1 RECEPTORS FOR TREATING PAIN AND PREVENTING CARTILAGE DEGRADATION | BDKRB1, BDKRB2, EDNRB | CHRM2 682/4885CHRM5 1495/4885ADRA2C 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.