Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854548 | 0.81 | LMNA (0.43) | SLC7A5ACACBLMNAHSD17B10HSP90AA1 | |
| SCHEMBL3854874 | 0.79 | NOTUM (0.48) | ACACBLMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL3886309 | 0.79 | LMNA (0.43) | SLC7A5ACACBLMNAHSD17B10KDM4E | |
| SCHEMBL3861714 | 0.79 | LMNA (0.42) | ACACBLMNAHSD17B10HSP90AA1KDM4E | |
| SCHEMBL3854478 | 0.78 | LMNA (0.42) | SLC7A5LMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL3355550 | 0.78 | LMNA (0.42) | ACACBLMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL3858278 | 0.78 | LMNA (0.41) | SLC7A5ACACBLMNAHSD17B10HSP90AA1 | |
| SCHEMBL3855535 | 0.75 | LMNA (0.41) | ACACBLMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL5158669 | 0.75 | LMNA (0.39) | ACACBLMNAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL3854906 | 0.74 | LMNA (0.52) | LMNAHSD17B10KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |