Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409134 | 0.88 | CDK4 (0.47) | CDK2CDK4 | |
| SCHEMBL5276382 | 0.86 | CDK2 (0.53) | CCNE1CDK2CDK4KDRSYK | |
| SCHEMBL27803615 | 0.85 | EGFR (0.42) | TGFBR1AKT1AKT2TGFBR2CCNE1 | |
| SCHEMBL415581 | 0.80 | CDK4 (0.47) | TGFBR1CDK2CDK4MAPK14 | |
| SCHEMBL412686 | 0.78 | IGF1R (0.49) | AKT1AKT2CDK2CDK4 | |
| SCHEMBL414224 | 0.76 | AKT1 (0.46) | AKT1AKT2CDK2CDK4 | |
| SCHEMBL413069 | 0.76 | IGF1R (0.47) | CDK2CDK4 | |
| SCHEMBL414374 | 0.76 | IGF1R (0.46) | TGFBR1CDK2CDK4KDR | |
| SCHEMBL411784 | 0.76 | IGF1R (0.47) | CDK2CDK4 | |
| SCHEMBL409151 | 0.76 | IGF1R (0.47) | CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546112-A4 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC INC (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1546112-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA Inc. (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004021989-A2 | IMIDAZOLOPYRIDINES AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2004-03-18 | — | — | WO | claimed |
| WO-2008013928-A2 | TREATMENT OF CANCER WITH INTERFERON GENE DELIVERY IN COMBINATION WITH A TGF-BETA INHIBITOR | BIOGEN IDEC MA INC. (US) | 2008-01-31 | — | — | WO | disclosed |