Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.53 |
| ▸ | CDK4 | P11802 | 3/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157280 | 0.86 | TGFBR1 (0.38) | CDK2CCNE1CDK4SYKKDR | |
| SCHEMBL409134 | 0.84 | CDK4 (0.47) | CDK2CDK4IGF1R | |
| SCHEMBL27803615 | 0.81 | EGFR (0.42) | CDK2CCNE1CDK4EGFRKDR | |
| SCHEMBL409700 | 0.80 | CDK2 (0.61) | CDK2CCNE1CDK4GSK3BIGF1R | |
| SCHEMBL701721 | 0.78 | CDK2 (0.55) | CDK2CCNE1CDK4CAMK2DIKBKB | |
| SCHEMBL7981339 | 0.77 | CDK2 (0.75) | CDK2CCNE1CDK4MAPK8PIK3CG | |
| SCHEMBL700021 | 0.77 | CDK2 (0.54) | CDK2CCNE1CDK4CAMK2DMAPK8 | |
| SCHEMBL415581 | 0.76 | CDK4 (0.47) | CDK2CDK4IGF1R | |
| SCHEMBL7977194 | 0.76 | CDK2 (0.55) | CDK2CCNE1CDK4CAMK2DGSK3B | |
| SCHEMBL412686 | 0.76 | IGF1R (0.49) | CDK2CDK4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |