Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206665 | 0.86 | SSTR4 (0.45) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL4052851 | 0.85 | KMT2A (0.48) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL4079658 | 0.84 | SSTR4 (0.43) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL207581 | 0.84 | POLB (0.46) | SSTR4SSTR1KMT2ATHRBHPGD | |
| SCHEMBL206157 | 0.83 | NPC1 (0.46) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL206736 | 0.83 | HPGD (0.48) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL4075132 | 0.83 | SSTR4 (0.43) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL2987319 | 0.83 | MEN1 (0.47) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL5161290 | 0.82 | SSTR4 (0.42) | SSTR4SSTR1KMT2AMEN1OPRM1 | |
| SCHEMBL206288 | 0.82 | ALDH1A1 (0.50) | KMT2AMEN1NPC1SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536323-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1745010-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-01-24 | — | — | EP | claimed |
| WO-2005110974-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |
| EP-1745010-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005110974-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |