Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 7/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TERT | O14746 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608390 | 0.83 | FAAH (0.58) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| Bromide SCHEMBL28986423 | 0.76 | FAAH (0.65) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL869143 | 0.75 | FAAH (0.67) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL21751441 | 0.75 | FAAH (0.67) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL9212159 | 0.75 | FAAH (0.67) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL28610213 | 0.73 | FAAH (0.65) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL21964138 | 0.73 | FAAH (0.65) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL28992675 | 0.73 | FAAH (0.65) | FAAHCES1SOAT1CYP1A2CYP2C19 | |
| SCHEMBL28846296 | 0.73 | FAAH (0.50) | FAAHCES1CYP1A2KMT2AMEN1 | |
| SCHEMBL8655383 | 0.73 | FAAH (0.69) | FAAHCES1SOAT1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7195864-B2 | Silver halide photographic light-sensitive material and aqueous coating composition | FUJI PHOTO FILM CO., LTD. (JP) | 2007-03-27 | — | — | US | disclosed |
| EP-1750173-A1 | Silver halide photosensitive material and packaged body containing the same | Fuji Photo Film Co., Ltd. (JP) | 2007-02-07 | — | — | EP | disclosed |
| US-7049055-B2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 2006-05-23 | — | — | US | disclosed |
| US-20050221239-A1 | Silver halide photographic material | FUJIFILM CORPORATION (JP) | 2005-10-06 | — | — | US | disclosed |
| US-20050142505-A1 | Silver halide photographic light-sensitive material and aqueous coating composition | FUJI PHOTO FILM CO., LTD. | 2005-06-30 | — | — | US | disclosed |
| EP-0476521-B1 | Silver halide photographic material and method for processing the same | FUJI PHOTO FILM CO LTD (JP) | 1997-12-03 | — | — | EP | disclosed |
| US-5674675-A | SILVER HALIDE EMULSION LAYER INCLUDES COLLOIDAL SILICA; IMPROVED PRESSURE RESISTANCE WITHOUT LOWERING PHOTOGRAPHIC SENSITIVITY | FUJI PHOTO FILM CO., LTD. (JP) | 1997-10-07 | — | — | US | disclosed |
| EP-0404142-B1 | Process for preparing silver halide emulsion | FUJI PHOTO FILM CO LTD (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5498511-A | BLACK AND WHITE, ASCORBIC ACID DEVELOPER, A TELLURIUM AND/OR A SELENIUM SENSITIZER, SILVER THIOCYANATE, SILVER SELENOCYANATE | FUJI PHOTO FILM CO., LTD. (JP) | 1996-03-12 | — | — | US | disclosed |
| EP-0401709-B1 | X-ray photographic material | FUJI PHOTO FILM CO LTD (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-5230994-A | Light sensitive elements | FUJI PHOTO FILM CO., LTD. (JP) | 1993-07-27 | — | — | US | disclosed |
| US-5190855-A | Hydroxypolyazaindene Complexing Agent | FUJI PHOTO FILM CO., LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| US-5147769-A | Image sharpness | FUJI PHOTO FILM CO., LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| US-5114838-A | Forming silver halide in an emulsion and complexing, adding a sulfur sensitizer and a gold sensitizer with nitrogen heterocycles | FUJI PHOTO FILM CO., LTD. (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0476521-A2 | Silver halide photographic material and method for processing the same | FUJI PHOTO FILM CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-5079134-A | X-ray film with improved sharpness, reduced crossover, dye which absorbs in sensitive region of silver halide emulsion | FUJI PHOTO FILM CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| US-5028520-A | Polyhydroxybenzene Compound, Reduction of Reflection Index, Crossover Elimination | FUJI PHOTO FILM CO., LTD. (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0404142-A1 | Process for preparing silver halide emulsion | Fuji Photo Film Co., Ltd. (JP) | 1990-12-27 | — | — | EP | disclosed |
| US-4965180-A | SUPPORT, SUBBING LAYER, AQUEOUS POLYMER LATEX | FUJII PHOTO FILM CO., LTD. (JP) | 1990-10-23 | — | — | US | disclosed |
| US-4942114-A | FLUORESCENT, REFLECTIVE | FUJI PHOTO FILM CO., LTD. (JP) | 1990-07-17 | — | — | US | disclosed |