Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.60 |
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258773 | 0.91 | HDAC1 (0.72) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL4258770 | 0.91 | HDAC1 (0.72) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL4895447 | 0.81 | HDAC1 (0.54) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL1566551 | 0.79 | HDAC1 (0.69) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL11830072 | 0.79 | GSK3B (0.52) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL5161843 | 0.79 | HDAC1 (0.63) | HDAC1HDAC2HDAC3HDAC6HDAC11 | |
| SCHEMBL4259730 | 0.77 | THRB (0.52) | NAMPTCYP3A4KMT2AALDH1A1HTT | |
| SCHEMBL4259731 | 0.77 | THRB (0.52) | NAMPTCYP3A4KMT2AALDH1A1HTT | |
| SCHEMBL4255531 | 0.75 | HDAC1 (1.00) | HDAC1NAMPTHDAC2HDAC3HDAC6 | |
| SCHEMBL4255532 | 0.75 | HDAC1 (1.00) | HDAC1NAMPTHDAC2HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |