Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713478 | 0.88 | HRH3 (0.45) | HRH3PDE4BOPRM1OPRD1OPRK1 | |
| SCHEMBL5713443 | 0.86 | HRH3 (0.39) | HRH3HRH1P2RX3OPRM1OPRD1 | |
| SCHEMBL5171940 | 0.86 | CYP4F2 (0.35) | HRH3HRH1 | |
| SCHEMBL5158952 | 0.83 | HRH3 (0.43) | HRH3HRH1P2RX3OPRM1OPRD1 | |
| SCHEMBL5161049 | 0.83 | HRH3 (0.39) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5170762 | 0.81 | SMO (0.33) | — | |
| SCHEMBL6223627 | 0.81 | HRH3 (0.56) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161959 | 0.81 | HRH3 (0.42) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5551729 | 0.79 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL5159375 | 0.79 | STAT3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |