Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713479 | 0.88 | HRH3 (0.46) | HRH3OPRM1OPRD1OPRK1P2RX3 | |
| SCHEMBL5171948 | 0.87 | SLC18A2 (0.33) | HRH3 | |
| SCHEMBL5713447 | 0.87 | HRH3 (0.37) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5170766 | 0.84 | SMO (0.34) | HRH3MTNR1BTP53KDM4C | |
| SCHEMBL5158947 | 0.83 | HRH3 (0.45) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161059 | 0.83 | OPRM1 (0.41) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL6223629 | 0.82 | HRH3 (0.54) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5161964 | 0.82 | HRH3 (0.40) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL5551732 | 0.81 | MTNR1B (0.50) | MTNR1B | |
| SCHEMBL5159383 | 0.80 | STAT3 (0.37) | OPRM1OPRD1OPRK1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756094-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005123723-A1 | 3-CYCLOALKYLBENZAZEPINES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-12-29 | — | — | WO | disclosed |