Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 15/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 15/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 14/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 14/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 14/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10512222 | 0.98 | CHRM4 (0.62) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL5395161 | 0.92 | SIGMAR1 (0.64) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL11413546 | 0.92 | SIGMAR1 (0.64) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL28270229 | 0.92 | SIGMAR1 (0.64) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL11765945 | 0.91 | SIGMAR1 (0.54) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL4862217 | 0.86 | SMN1; SMN2 (0.59) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL4431781 | 0.86 | SIGMAR1 (0.66) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL14288466 | 0.85 | CHRM4 (0.50) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL31067545 | 0.85 | SIGMAR1 (0.49) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 | |
| SCHEMBL17073435 | 0.85 | SIGMAR1 (0.49) | SIGMAR1CHRM4CHRM3CHRM5CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081682-B1 | LITHIUM REAGENT POROUS METAL OXIDE COMPOSITIONS | SIGNA CHEMISTRY INC (US) | 2018-05-30 | — | — | EP | disclosed |
| EP-3218425-A1 | SILICONE COMPOUNDS | The Procter and Gamble Company (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077513-A1 | SILICONE COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 2016-05-19 | — | — | WO | disclosed |
| US-20140306153-A1 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | SIGNA CHEMISTRY, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| US-20140306153-A1 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | SIGNA CHEMISTRY, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| US-20120235084-A1 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | SIGNA CHEMISTRY, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120235084-A1 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | SIGNA CHEMISTRY, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2012113889-A1 | PROCESSES FOR THE STEREOSELECTIVE PREPARATION OF P-CHIRAL FOUR -COORDINATED PHOSPHORUS BORANE COMPOUNDS AND P-CHIRAL THREE-COORDINATED PHOSPHORUS COMPOUNDS | UNIVERSITY COLLEGE DUBLIN (IE) | 2012-08-30 | — | — | WO | disclosed |
| US-8197707-B2 | Lithium-porous metal oxide compositions and lithium reagent-porous metal compositions | SIGNA CHEMISTRY LLC (US) | 2012-06-12 | — | — | US | disclosed |
| US-8197707-B2 | Lithium-porous metal oxide compositions and lithium reagent-porous metal compositions | SIGNA CHEMISTRY LLC (US) | 2012-06-12 | — | — | US | disclosed |
| US-20080111104-A1 | mixing liquid lithium metal with a porous metal oxide in an inert atmosphere under exothermic conditions sufficient to absorb the liquid lithium metal into the porous metal oxide pores, reacting lithium-metal oxide with a alkyl halide to form alkyllithium-metal oxide reagent used in various reactions | SIGNA CHEMISTRY, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| US-20080111104-A1 | mixing liquid lithium metal with a porous metal oxide in an inert atmosphere under exothermic conditions sufficient to absorb the liquid lithium metal into the porous metal oxide pores, reacting lithium-metal oxide with a alkyl halide to form alkyllithium-metal oxide reagent used in various reactions | SIGNA CHEMISTRY, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| WO-2008031101-A2 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | SIGNA CHEMISTRY, LLC (US) | 2008-03-13 | — | — | WO | disclosed |
| EP-1751170-A1 | CHIRAL PHOSPHORUS COMPOUNDS | UNIVERSITY COLLEGE DUBLIN (IE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005118603-A1 | CHIRAL PHOSPHORUS COMPOUNDS | UNIVERSITY COLLEGE DUBLIN (IE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140306153-A1 | LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS | NR1I2, SLCO2B1, NR1I3 | SIGMAR1 328/4885CHRM4 3223/4885CHRM3 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.