Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31036036 | 0.98 | HRH1 (0.35) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL29263707 | 0.98 | HRH1 (0.35) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL14835009 | 0.94 | HSP90AA1 (0.34) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL9741925 | 0.88 | HDAC3 (0.31) | HDAC3HDAC1HDAC2HDAC6HRH1 | |
| SCHEMBL1427937 | 0.85 | — | — | |
| SCHEMBL28362525 | 0.84 | HSP90AA1 (0.40) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL9659760 | 0.79 | HRH1 (0.53) | HSP90AA1HRH1HRH4HRH3 | |
| SCHEMBL294018 | 0.79 | HSP90AA1 (0.33) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL10949970 | 0.79 | HRH1 (0.36) | HDAC3HDAC1HDAC2HDAC6HSP90AA1 | |
| SCHEMBL1325052 | 0.79 | TDP1 (0.48) | CYP3A4CYP2C9CYP2C19HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938497-B1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | GENENTECH INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20020151473-A1 | Constrained helical peptides and methods of making same | BRAISTED ANDREW C (US) | 2002-10-17 | — | — | US | disclosed |
| US-6271198-B1 | CYCLIC PEPTIDES | GENENTECH, INC. | 2001-08-07 | — | — | US | disclosed |
| EP-0938497-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | Genentech, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998020036-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | GENENTECH, INC. (US) | 1998-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151473-A1 | Constrained helical peptides and methods of making same | TIMCC, FURIN, NGLY1 | HDAC3 4556/4885HDAC1 4643/4885HDAC2 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.