Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263707 | 0.90 | HRH1 (0.35) | HDAC3HDAC1HDAC2HDAC6HRH1 | |
| SCHEMBL31036036 | 0.90 | HRH1 (0.35) | HDAC3HDAC1HDAC2HDAC6HRH1 | |
| SCHEMBL5159759 | 0.88 | HDAC3 (0.36) | HDAC3HDAC1HDAC2HDAC6HRH1 | |
| SCHEMBL14835009 | 0.82 | HSP90AA1 (0.34) | HDAC3HDAC1HDAC2HDAC6HRH1 | |
| SCHEMBL10417000 | 0.77 | HRH1 (0.56) | HRH1 | |
| SCHEMBL10461495 | 0.77 | HRH1 (0.56) | HRH1 | |
| SCHEMBL1427937 | 0.74 | — | — | |
| SCHEMBL10460727 | 0.74 | HRH1 (0.51) | HRH1 | |
| SCHEMBL10417735 | 0.74 | HRH1 (0.51) | HRH1 | |
| SCHEMBL28362525 | 0.74 | HSP90AA1 (0.40) | HDAC3HDAC1HDAC2HDAC6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5149698-A | Pyrimidinyl alkyleneoxy bronchodilator agent | GLAXO GROUP LIMITED (GB) | 1992-09-22 | — | — | US | disclosed |
| US-4996218-A | Bronchodilator, antiulcer agent, cardiovascular disorders | GLAXO GROUP LIMITED (GB) | 1991-02-26 | — | — | US | disclosed |
| EP-0303464-A2 | Chloroaniline derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |