Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LONP1 | P36776 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9992063 | 0.84 | ATM (0.36) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL19003627 | 0.80 | POLB (0.35) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL18595067 | 0.78 | SMN1; SMN2 (0.37) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL31152640 | 0.78 | HSP90AA1 (0.34) | KDM4EALDH1A1SMN1; SMN2HSP90AA1ATM | |
| SCHEMBL18881769 | 0.77 | ATM (0.34) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL7973738 | 0.77 | KDM4E (0.40) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL11266634 | 0.75 | HRH1 (0.38) | ALDH1A1ATMHRH1 | |
| SCHEMBL28802112 | 0.74 | KDM4E (0.32) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E | |
| SCHEMBL6551622 | 0.73 | KCNA5 (0.51) | CYP2D6CYP2C9ALDH1A1SMN1; SMN2CHRM1 | |
| SCHEMBL26078416 | 0.73 | KDM4E (0.38) | CYP2D6CYP19A1CYP2C9CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938497-B1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | GENENTECH INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20020151473-A1 | Constrained helical peptides and methods of making same | BRAISTED ANDREW C (US) | 2002-10-17 | — | — | US | disclosed |
| US-6271198-B1 | CYCLIC PEPTIDES | GENENTECH, INC. | 2001-08-07 | — | — | US | disclosed |
| EP-0938497-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | Genentech, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998020036-A1 | CONSTRAINED HELICAL PEPTIDES AND METHODS OF MAKING SAME | GENENTECH, INC. (US) | 1998-05-14 | — | — | WO | disclosed |
| US-4638005-A | ELECTRON CARRIERS IN THE PHOTOENZYMATIC PRODUCTION OF HYDROGEN AND AMMONIA | THE COCA-COLA COMPANY | 1987-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020151473-A1 | Constrained helical peptides and methods of making same | TIMCC, FURIN, NGLY1 | CYP2D6 4767/4885CYP19A1 3734/4885CYP2C9 4587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.