Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.79 |
| ▸ | MMP9 | P14780 | 13/20 | 0.79 |
| ▸ | MMP13 | P45452 | 13/20 | 0.79 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934592 | 0.92 | MMP1 (0.79) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL5160292 | 0.91 | MMP1 (0.81) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6933054 | 0.91 | MMP1 (0.81) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6932292 | 0.90 | MMP1 (0.65) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6932117 | 0.89 | MMP1 (1.00) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL6928537 | 0.89 | MMP1 (1.00) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL5157944 | 0.88 | MMP1 (0.75) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6929947 | 0.88 | MMP1 (0.75) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6934963 | 0.83 | MMP1 (0.72) | MMP1MMP9MMP13LTA4HADAM17 | |
| SCHEMBL6933135 | 0.83 | MMP1 (0.81) | MMP1MMP9MMP13LTA4HADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777214-A2 | Novel aryloxy-alkyl-dialkylamines | Wyeth (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1025077-B1 | NOVEL ARYLOXY-ALKYL-DIALKYLAMINES | WYETH CORP (US) | 2007-02-28 | — | — | EP | disclosed |
| US-6268504-B1 | USED IN THE PRODUCTION OF PHARMACEUTICAL PRODUCTS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-31 | — | — | US | disclosed |
| US-6242605-B1 | Aryloxy-alkyl-dialkylamines | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-05 | — | — | US | disclosed |