Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10035358 | 0.93 | SMN1; SMN2 (0.69) | SMN1; SMN2HPGDHIF1AGAATDP1 | |
| SCHEMBL10035342 | 0.90 | SMN1; SMN2 (0.74) | SMN1; SMN2HPGDHIF1AGAATDP1 | |
| SCHEMBL10035351 | 0.90 | SMN1; SMN2 (0.74) | SMN1; SMN2HPGDHIF1AGAATDP1 | |
| SCHEMBL13401011 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDHIF1AGAATDP1 | |
| SCHEMBL10035359 | 0.83 | CYP19A1 (0.65) | SMN1; SMN2HPGDHIF1ACACNA2D1MAPT | |
| SCHEMBL10035331 | 0.83 | KDM4E (0.55) | SMN1; SMN2GAACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL10035327 | 0.81 | CYP3A4 (0.62) | SMN1; SMN2HPGDHIF1ACACNA2D1MAPT | |
| SCHEMBL10035353 | 0.81 | CYP3A4 (0.62) | SMN1; SMN2HPGDHIF1ACACNA2D1MAPT | |
| SCHEMBL10035354 | 0.81 | CYP2D6 (0.70) | SMN1; SMN2HPGDHIF1ACACNA2D1MAPT | |
| SCHEMBL10035317 | 0.80 | AVPR1A (0.54) | SMN1; SMN2HPGDGAACYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749208-A2 | FUNCTIONAL GHS-R ANTAGONISTS | NOVO NORDISK A/S (DK) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005114180-A2 | FUNCTIONAL GHS-R ANTAGONISTS | NOVO NORDISK A/S (DK) | 2005-12-01 | — | — | WO | disclosed |