Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.60 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | STS | P08842 | 8/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.57 |
| ▸ | SHBG | P04278 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158985 | 0.90 | HSD17B1 (0.61) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL29169376 | 0.90 | HSD17B1 (0.72) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL29169374 | 0.90 | HSD17B1 (0.72) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL19688370 | 0.90 | HSD17B1 (0.72) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL6266355 | 0.87 | STS (0.70) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL6265194 | 0.87 | STS (0.70) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL1234807 | 0.86 | STS (0.71) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL5158357 | 0.85 | CYP19A1 (0.71) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL30804206 | 0.83 | CYP19A1 (0.71) | CYP19A1HSD17B1ESR1STSCYP3A4 | |
| SCHEMBL9236798 | 0.82 | CYP19A1 (0.73) | CYP19A1HSD17B1ESR1STSCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1405860-B1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | STANFORD RES INST INT (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1405860-A1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | SRI INTERNATIONAL (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-1042354-B1 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1042354-A2 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 2000-10-11 | — | — | EP | disclosed |
| US-6046186-A | ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | SRI INTERNATIONAL (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999033858-A9 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 1999-10-28 | — | — | WO | disclosed |
| WO-1999033858-A2 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1999-07-08 | — | — | WO | disclosed |