Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | FPR1 | P21462 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176921 | 0.94 | MAPT (0.44) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5161856 | 0.84 | MAPT (0.49) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5156698 | 0.83 | MAPT (0.43) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL6482543 | 0.81 | MAPT (0.41) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5161625 | 0.78 | MAPT (0.39) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5160136 | 0.76 | SLC18A3 (0.53) | MAPTPKMKDM1AADRA2ADRD2 | |
| SCHEMBL5158454 | 0.76 | ALDH1A1 (0.42) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5161360 | 0.75 | MAPT (0.46) | MAPTPKMTACR1KDM1AFPR1 | |
| SCHEMBL5156095 | 0.74 | MAPT (0.41) | MAPTPKMTACR1FPR1DRD2 | |
| SCHEMBL5158881 | 0.73 | MAPT (0.48) | MAPTPKMTACR1KDM1AFPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748984-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005110987-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |