Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 5/20 | 0.31 |
| ▸ | MAOB | P27338 | 5/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162043 | 1.00 | KDM1A (0.41) | KDM1ATACR1GBA1GAAALDH1A1 | |
| SCHEMBL5159298 | 1.00 | KDM1A (0.41) | KDM1ATACR1GBA1GAAALDH1A1 | |
| SCHEMBL5161943 | 1.00 | KDM1A (0.41) | KDM1ATACR1GBA1GAAALDH1A1 | |
| SCHEMBL5161948 | 1.00 | KDM1A (0.41) | KDM1ATACR1GBA1GAAALDH1A1 | |
| SCHEMBL14446220 | 0.83 | KDM1A (0.41) | KDM1ATACR1ALDH1A1MAPTMAOA | |
| SCHEMBL5161755 | 0.74 | GBA1 (0.38) | KDM1ATACR1GBA1MAOAMAOB | |
| SCHEMBL14446228 | 0.74 | GBA1 (0.38) | KDM1ATACR1GBA1MAOAMAOB | |
| SCHEMBL5414950 | 0.74 | GBA1 (0.38) | KDM1ATACR1GBA1MAOAMAOB | |
| SCHEMBL5161190 | 0.73 | HDAC2 (0.36) | TACR1GBA1CTSCMAPTHDAC2 | |
| Hydrochloric Acid SCHEMBL5404669 | 0.72 | TACR1 (0.37) | KDM1ATACR1GBA1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241798-B2 | NK1 antagonists | PFIZER INC. (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1756056-A1 | AZA-BICYCLO[3.1.0]HEX-1-YL DERIVATIVES ACTIVE AS NK1 ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005121085-A1 | AZA-BICYCLO`3.1.0!HEX-1-YL DERIVATIVES ACTIVE AS NK1 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050272800-A1 | NK1 antagonists | PFIZER INC | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272800-A1 | NK1 antagonists | TACR1, TACR2, TAC3 | KDM1A 2128/4885TACR1 1/4885GBA1 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.