TAC3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3996940	1.00	6/20
SCHEMBL3996944	1.00	6/20
SCHEMBL4000054	0.91	6/20
SCHEMBL4141630	0.91	6/20
SCHEMBL4141632	0.90	6/20
SCHEMBL4141635	0.90	6/20
SCHEMBL4002162	0.90	6/20
SCHEMBL4002164	0.90	6/20
SCHEMBL3998480	0.88	6/20
SCHEMBL3998484	0.88	6/20
SCHEMBL4141799	0.85	6/20
SCHEMBL4141802	0.85	6/20
SCHEMBL4142084	0.84	6/20
SCHEMBL4142087	0.84	6/20
SCHEMBL4141387	0.83	6/20
SCHEMBL4141390	0.83	6/20
SCHEMBL4141048	0.82	6/20
SCHEMBL4000380	0.82	6/20
SCHEMBL3996753	0.82	6/20
SCHEMBL3996754	0.82	6/20

Clinical trials — most relevant to TAC3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Dextrose Versus Saline Infusion on Intrathecal Morphine-Induced Postoperative Nausea and Vomiting During Gynecological Abdominal Surgeries: Randomized Controlled Double-blind Study	PHASE4	NOT_YET_RECRUITING
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration	PHASE4	COMPLETED
Ictal and Interictal Inflammatory Markers in Migraine	PHASE4	COMPLETED
Continuous Infusion of First-Generation 5-HT3 Receptor Antagonists in Combination With Dexamethasone	PHASE3	COMPLETED
Prevention of Breakthrough CINV in Patients Receiving Moderately or Highly Emetogenic Chemotherapy	PHASE2	UNKNOWN
Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy	PHASE2	RECRUITING
Capsaicin to Prevent Delayed Chemotherapy Induced Nausea and Vomiting (CapCIN)	PHASE2	COMPLETED
Trastuzumab Deruxtecan in First-Line HER2-Positive Metastatic Breast Cancer With Proactive Toxicity Management	PHASE2	RECRUITING
Efficacy and Safety of Azilsartan in Subjects With Essential Hypertension	PHASE2	COMPLETED
The Effects of Atorvastatin on the Nitric Oxide-system in Healthy Young Man	PHASE2	COMPLETED
Psychopharmacology for Cocaine Dependence - Buspirone	PHASE2	COMPLETED
Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ	PHASE1	COMPLETED
Neuroimmune Effects of Opioid Administration	PHASE1	COMPLETED
Precision Medicine for Nociception, Sngception and Proprioception.	nan	RECRUITING
Precision Medicine for Sng/Pain Control	nan	COMPLETED
Role of Specific microRNAs in Cluster Headache	nan	RECRUITING
Effect of Electroacupuncture on Sensitive Symptoms of Distal Diabetic Peripheral Neuropathy	nan	UNKNOWN
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction	nan	COMPLETED
Somatic Psychoeducational Intervention	nan	COMPLETED
Affective Touch, Hedonia and Suicidal Behavior	nan	COMPLETED
Accelerated Rule Out of Myocardial Infarction	nan	COMPLETED
Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels	nan	RECRUITING
TACS on High-inflammatory and Refractory Depression	nan	RECRUITING
Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells	nan	COMPLETED
PACAP Induced Migraine Attacks in Patients With High and Low Genetic Load	nan	COMPLETED
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome	nan	COMPLETED
Role of Substance P in Post-Traumatic Stress Disorder	nan	COMPLETED
Psychometric Properties of the Chinese Version of PeNAT	nan	UNKNOWN
Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC.	nan	COMPLETED
Reproductive Aging and Obstructive Sleep Apnea	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TAC3 binder may also engage these)

Protein	Name	Similarity
P08858	—	1.000	P08858 →
P67934	—	1.000	P67934 →
P09681	—	0.996	P09681 →
Q4QXT8	—	0.996	Q4QXT8 →
P08435	—	0.996	P08435 →
P55099	—	0.995	P55099 →
P04563	—	0.995	P04563 →
P07808	—	0.994	P07808 →
Q13519	—	0.994	Q13519 →
Q99N14	—	0.993	Q99N14 →
A0A0F7YZQ7	—	0.993	A0A0F7YZQ7 →
Q0VC44	—	0.992	Q0VC44 →
P14765	—	0.992	P14765 →
Q1HA14	—	0.992	Q1HA14 →
F1QQI2	—	0.991	F1QQI2 →
Q9PTQ4	—	0.991	Q9PTQ4 →
P69155	—	0.991	P69155 →
Q9GK30	—	0.991	Q9GK30 →
Q9Y5Q6	—	0.990	Q9Y5Q6 →
O35417	—	0.990	O35417 →
P48756	—	0.990	P48756 →
Q0VBW8	—	0.990	Q0VBW8 →
P01283	—	0.990	P01283 →
P08948	—	0.990	P08948 →
Q9MYK8	—	0.990	Q9MYK8 →
P41547	—	0.989	P41547 →
Q8WRC7	—	0.988	Q8WRC7 →
D3Z752	—	0.988	D3Z752 →
Q9I8P3	—	0.988	Q9I8P3 →
M0R8L2	—	0.988	M0R8L2 →