Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 17/20 | 0.64 |
| ▸ | BCR | P11274 | 16/20 | 0.64 |
| ▸ | LYN | P07948 | 5/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.64 |
| ▸ | KIT | P10721 | 4/20 | 0.64 |
| ▸ | LCK | P06239 | 4/20 | 0.64 |
| ▸ | CSF1R | P07333 | 4/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.64 |
| ▸ | FYN | P06241 | 2/20 | 0.64 |
| ▸ | FGR | P09769 | 2/20 | 0.64 |
| ▸ | BRAF | P15056 | 2/20 | 0.64 |
| ▸ | NQO2 | P16083 | 2/20 | 0.64 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.64 |
| ▸ | ABL2 | P42684 | 2/20 | 0.64 |
| ▸ | FRK | P42685 | 2/20 | 0.64 |
| ▸ | BLK | P51451 | 2/20 | 0.64 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14789747 | 0.93 | ABL1 (0.74) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL718122 | 0.89 | ABL1 (0.58) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL716920 | 0.86 | ABL1 (0.67) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL5503213 | 0.86 | ABL1 (0.51) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL717185 | 0.86 | ABL1 (0.56) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL717868 | 0.84 | KIT (0.69) | ABL1BCRLYNKITCSF1R | |
| SCHEMBL716307 | 0.84 | KDM4E (0.52) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL5971854 | 0.82 | ABL1 (0.80) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL5174867 | 0.82 | CSF1R (0.52) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL718546 | 0.80 | ABL1 (0.49) | ABL1BCRLYNPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758654-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB Science (FR) | 2007-03-07 | — | — | EP | disclosed |
| EP-1746990-A1 | USE OF MAST CELLS INHIBITORS FOR TREATING PATIENTS EXPOSED TO CHEMICAL OR BIOLOGICAL WEAPONS | AB Science (FR) | 2007-01-31 | — | — | EP | disclosed |
| EP-1624873-A2 | USE OF TYROSINE KINASE INHIBITORS FOR TREATING CEREBRAL ISCHEMIA | AB Science (FR) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005115304-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBRODYSPLASIA | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005112920-A1 | USE OF MAST CELLS INHIBITORS FOR TREATING PATIENTS EXPOSED TO CHEMICAL OR BIOLOGICAL WEAPONS | AB SCIENCE (FR) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005102455-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |
| EP-1525200-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB Science (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004096225-A2 | USE OF TYROSINE KINASE INHIBITORS FOR TREATING CEREBRAL ISCHEMIA | AB SCIENCE (FR) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004014903-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2004-02-19 | — | — | WO | disclosed |