Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.51 |
| ▸ | BCR | P11274 | 8/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | FGR | P09769 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | SLC25A6 | P12236 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL716307 | 0.88 | KDM4E (0.52) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL717582 | 0.86 | ABL1 (0.48) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL5162199 | 0.86 | ABL1 (0.64) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL718546 | 0.86 | ABL1 (0.49) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL4902752 | 0.84 | ALDH1A1 (0.54) | CSF1RBRAFKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14789747 | 0.83 | ABL1 (0.74) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL714837 | 0.82 | NPC1 (0.53) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL720659 | 0.82 | ABL1 (0.59) | ABL1PDGFRABCRPDGFRBEGFR | |
| SCHEMBL718122 | 0.82 | ABL1 (0.58) | ABL1PDGFRABCRKITPDGFRB | |
| SCHEMBL717185 | 0.79 | ABL1 (0.56) | ABL1PDGFRABCRKITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758654-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB Science (FR) | 2007-03-07 | — | — | EP | disclosed |
| EP-1653934-A2 | USE OF C-KIT INHIBITORS FOR TREATING TYPE II DIABETES | AB Science (FR) | 2006-05-10 | — | — | EP | disclosed |
| EP-1624873-A2 | USE OF TYROSINE KINASE INHIBITORS FOR TREATING CEREBRAL ISCHEMIA | AB Science (FR) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005115304-A2 | USE OF C-KIT INHIBITORS FOR TREATING FIBRODYSPLASIA | AB SCIENCE (FR) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005102455-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |
| EP-1525200-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB Science (FR) | 2005-04-27 | — | — | EP | disclosed |
| WO-2005016323-A2 | USE OF C-KIT INHIBITORS FOR TREATING TYPE II DIABETES | AB SCIENCE (FR) | 2005-02-24 | — | — | WO | disclosed |
| WO-2004096225-A2 | USE OF TYROSINE KINASE INHIBITORS FOR TREATING CEREBRAL ISCHEMIA | AB SCIENCE (FR) | 2004-11-11 | — | — | WO | disclosed |
| US-20040110810-A1 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | AB SCIENCE | 2004-06-10 | — | — | US | disclosed |
| WO-2004014903-A1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110810-A1 | e.g., 2-(2-methyl-5-amino)phenyl-4-(3-pyridyl)-thiazole; c-kit inhibitors; treating cell proliferative, metabolic, allergic, and degenerative disorders. | KIT, MAP3K2, CMA1 | ABL1 251/4885PDGFRA 159/4885BCR 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.