Sugi Predict

Sugi Predict / Compounds / SCHEMBL516341

SCHEMBL516341

SCHEMBL516341

NC(Cc1ccccc1)C([O])=O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 2/20 0.73
▸ ALPI P09923 1/20 0.73
▸ PKM P14618 1/20 0.73
▸ PTGS1 P23219 1/20 0.73
▸ XIAP P98170 1/20 0.73
▸ SLC15A1 P46059 1/20 0.61
▸ LTA4H P09960 1/20 0.58
▸ SLC1A3 P43003 2/20 0.56
▸ SLC1A2 P43004 2/20 0.56
▸ SLC1A1 P43005 2/20 0.56
▸ HDAC8 Q9BY41 2/20 0.54
▸ EPHX1 P07099 2/20 0.54
▸ CYP1A2 P05177 1/20 0.54
▸ LAP3 P28838 3/20 0.52
▸ ANPEP P15144 1/20 0.52
▸ CTSC P53634 1/20 0.51
▸ TAAR1 Q96RJ0 2/20 0.50
▸ SRR Q9GZT4 1/20 0.50
▸ MAOA P21397 1/20 0.50
▸ SLC6A2 P23975 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28940160 1.00 SLC7A5 (0.73) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL8609117 0.87 SLC7A5 (0.96) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine SCHEMBL8609120 0.87 SLC7A5 (0.96) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL28126466 0.85 SLC7A5 (0.92) SLC7A5ALPIPKMPTGS1XIAP
D-Phenylalanine SCHEMBL28862316 0.85 SLC7A5 (0.92) SLC7A5ALPIPKMPTGS1XIAP
SCHEMBL23159186 0.84 SLC7A5 (1.00) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine SCHEMBL8119 0.84 SLC7A5 (1.00) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL16398196 0.84 SLC7A5 (1.00) SLC7A5ALPIPKMPTGS1XIAP
Dl-Phenylalanine SCHEMBL385804 0.84 SLC7A5 (1.00) SLC7A5ALPIPKMPTGS1XIAP
Phenylalanine SCHEMBL43671 0.84 SLC7A5 (1.00) SLC7A5ALPIPKMPTGS1XIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9789118-B2 Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof NOVARTIS AG (CH) 2017-10-17 — — US claimed
US-20140171363-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF NOVARTIS AG (CH) 2014-06-19 — — US claimed
EP-2598486-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS Novartis AG (CH) 2013-06-05 — — EP claimed
WO-2012013716-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS NOVARTIS AG (CH) 2012-02-02 — — WO claimed
US-5929103-A ANTICARCINOGENIC AGENTS DONG WHA PHARM. IND. CO., LTD. (KR) 1999-07-27 — — US claimed
US-11267797-B2 Anticancer agent KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2022-03-08 — — US disclosed
US-20200317630-A1 ANTICANCER AGENT KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2020-10-08 — — US disclosed
US-10689355-B2 Anticancer agent Kyoto Pharmaceuticals Industries, Ltd. (JP) 2020-06-23 — — US disclosed
EP-3153508-B1 NAPHTHOFURAN DERIVATIVES FOR USE AS ANTICANCER AGENTS KYOTO PHARMA IND (JP) 2020-03-18 — — EP disclosed
US-20190322636-A1 NOVEL ANTICANCER AGENT KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2019-10-24 — — US disclosed
US-10377730-B2 Anticancer agent KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2019-08-13 — — US disclosed
US-20180265489-A1 NOVEL ANTICANCER AGENT KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2018-09-20 — — US disclosed
US-9789118-B2 Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof NOVARTIS AG (CH) 2017-10-17 — — US disclosed
US-20170121299-A1 NOVEL ANTICANCER AGENT KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2017-05-04 — — US disclosed
EP-3153508-A1 NOVEL ANTICANCER AGENT Kyoto Pharmaceutical Industries, Ltd. (JP) 2017-04-12 — — EP disclosed
US-20140171363-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF NOVARTIS AG (CH) 2014-06-19 — — US disclosed
US-8697739-B2 Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof NOVARTIS AG (CH) 2014-04-15 — — US disclosed
EP-2598486-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS Novartis AG (CH) 2013-06-05 — — EP disclosed
US-20120028969-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF NOVARTIS AG (CH) 2012-02-02 — — US disclosed
WO-2012013716-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS NOVARTIS AG (CH) 2012-02-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170121299-A1 NOVEL ANTICANCER AGENT NTPCR, TP53, NME1 SLC7A5 593/4885ALPI 804/4885PKM 3391/4885
US-20140171363-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF ACACA, ACACB, COASY SLC7A5 2059/4885ALPI 881/4885PKM 851/4885
US-20200317630-A1 ANTICANCER AGENT TP53, NTPCR, NQO1 SLC7A5 403/4885ALPI 364/4885PKM 2754/4885
US-11267797-B2 Anticancer agent TP53, NTPCR, NQO1 SLC7A5 403/4885ALPI 364/4885PKM 2754/4885
US-20180265489-A1 NOVEL ANTICANCER AGENT NTPCR, TP53, NME1 SLC7A5 593/4885ALPI 804/4885PKM 3391/4885
US-20190322636-A1 NOVEL ANTICANCER AGENT NTPCR, TP53, NME1 SLC7A5 593/4885ALPI 804/4885PKM 3391/4885
US-20120028969-A1 BICYCLIC ACETYL-COA CARBOXYLASE INHIBITORS AND USES THEREOF ACACA, ACACB, COASY SLC7A5 2059/4885ALPI 881/4885PKM 851/4885
US-10689355-B2 Anticancer agent TP53, NTPCR, NQO1 SLC7A5 403/4885ALPI 364/4885PKM 2754/4885
US-10377730-B2 Anticancer agent TP53, NTPCR, NQO1 SLC7A5 403/4885ALPI 364/4885PKM 2754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.