Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526194 | 0.88 | GAA (0.57) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL27675295 | 0.82 | GAA (0.52) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL28221360 | 0.82 | GAA (0.52) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL17585418 | 0.81 | TSHR (0.42) | GAATDP1LMNAHTT | |
| SCHEMBL756910 | 0.80 | PTPN1 (0.52) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL4641892 | 0.80 | GAA (0.50) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL14609496 | 0.80 | GAA (0.50) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL1151049 | 0.80 | GAA (0.50) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL7256741 | 0.80 | TDP1 (0.55) | GAACTBP2TDP1POLBAPEX1 | |
| SCHEMBL823410 | 0.80 | GAA (0.50) | GAACTBP2TDP1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765793-A1 | CETP INHIBITORS | Merck and Co., Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006014413-A1 | CETP INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |