SCHEMBL526194

SCHEMBL526194

O=C(Cc1ccc(F)cc1)Cc1ccc(F)cc1

nearest known ligand 0.67

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.57
CTBP2 P56545 1/20 0.55
POLB P06746 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
APEX1 P27695 1/20 0.52
SMN1; SMN2 Q16637 3/20 0.50
ALDH1A1 P00352 1/20 0.50
RAB9A P51151 1/20 0.50
EGFR P00533 1/20 0.50
ERBB2 P04626 1/20 0.50
LMNA P02545 2/20 0.48
HTT P42858 2/20 0.48
KMT2A Q03164 2/20 0.48
KDM4E B2RXH2 1/20 0.48
IDO1 P14902 1/20 0.46
CES2 O00748 1/20 0.46
CES1 P23141 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27675295 0.93 GAA (0.52) GAACTBP2POLBTDP1APEX1
SCHEMBL28221360 0.93 GAA (0.52) GAACTBP2POLBTDP1APEX1
SCHEMBL28191412 0.91 ALDH1A1 (0.62) GAACTBP2TDP1SMN1; SMN2ALDH1A1
SCHEMBL5163933 0.88 GAA (0.52) GAACTBP2POLBTDP1APEX1
SCHEMBL823410 0.86 GAA (0.50) GAACTBP2POLBTDP1APEX1
SCHEMBL7256741 0.86 TDP1 (0.55) GAACTBP2POLBTDP1APEX1
SCHEMBL756910 0.86 PTPN1 (0.52) GAACTBP2POLBTDP1APEX1
SCHEMBL14609496 0.86 GAA (0.50) GAACTBP2POLBTDP1APEX1
SCHEMBL1151049 0.86 GAA (0.50) GAACTBP2POLBTDP1APEX1
SCHEMBL12206806 0.86 TDP1 (0.50) GAACTBP2POLBTDP1APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117486681-A Preparation method of 3-aryl/alkyl-beta-anisole compound 中国海洋石油集团有限公司 2024-02-02 CN disclosed
CN-117486682-A Preparation method of functionalized beta-naphthalenyl ether compound 中国海洋石油集团有限公司 2024-02-02 CN disclosed
US-11370733-B2 Organic compound, organic light-emitting element, display device, imaging device, electronic device, illumination device, and moving object CANON KABUSHIKI KAISHA (JP) 2022-06-28 US disclosed
US-20220081378-A1 ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CANON KABUSHIKI KAISHA (JP) 2022-03-17 US disclosed
US-20200048171-A1 ORGANIC COMPOUND, ORGANIC LIGHT-EMITTING ELEMENT, DISPLAY DEVICE, IMAGING DEVICE, ELECTRONIC DEVICE, ILLUMINATION DEVICE, AND MOVING OBJECT CANON KABUSHIKI KAISHA (JP) 2020-02-13 US disclosed
EP-3608303-A1 ORGANIC COMPOUND, ORGANIC LIGHT-EMITTING ELEMENT, DISPLAY DEVICE, IMAGING DEVICE, ELECTRONIC DEVICE, ILLUMINATION DEVICE, AND MOVING OBJECT CANON KABUSHIKI KAISHA (JP) 2020-02-12 EP disclosed
EP-2598484-B1 PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF LEK PHARMACEUTICALS (SI) 2016-06-29 EP disclosed
US-9085538-B2 Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof LEK PHARMACEUTICALS D.D. (SI) 2015-07-21 US disclosed
US-20150126502-A1 INHIBITORS OF POLO-LIKE KINASE ELAN PHARM INC (US) 2015-05-07 US disclosed
EP-2516441-B1 PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE ELAN PHARM INC (US) 2015-01-21 EP disclosed
US-20020103400-A1 Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same CENTRAL GLASS COMPANY, LIMITED (JP) 2002-08-01 US disclosed
EP-0889920-B1 POLYPHENYLENE OLIGOMERS AND POLYMERS DOW CHEMICAL CO (US) 2002-02-13 EP disclosed
US-6288188-B1 ACETYLENIC POLYMERS; INTEGRATED CIRCUITS, DIELECTRICS, MICROELECTRONICS THE DOW CHEMICAL COMPANY 2001-09-11 US disclosed
EP-1121359-A1 IMIDAZO-ISOQUINOLINE COMPOUNDS, THEIR COMPOSITIONS AND USES THE PROCTER & GAMBLE COMPANY (US) 2001-08-08 EP disclosed
US-6159985-A Imidazo-isoquinoline compounds, their compositions and uses THE PROCTER & GAMBLE COMPANY (US) 2000-12-12 US disclosed
WO-2000021961-A1 IMIDAZO-ISOQUINOLINE COMPOUNDS, THEIR COMPOSITIONS AND USES THE PROCTER & GAMBLE COMPANY (US) 2000-04-20 WO disclosed
EP-0980872-A2 Catalysts based upon fulvene-metal complexes Bayer Aktiengesellschaft (DE) 2000-02-23 EP disclosed
US-5965679-A BASED A BISCYCLOPENTADIENONE AND AN AROMATIC DIACETYLENE; CURING; LOW DIELECTRIC; INTEGRATED CIRCUITS; MICROELECTRONICS; PRINTED CIRCUITS THE DOW CHEMICAL COMPANY (US) 1999-10-12 US disclosed
CN-1013671-B PREPARATION METHOD FOR PYRAZOLINES SCHERING AG (DE) 1991-08-28 CN disclosed
CN-86108628-A Preparation method for pyrazolines 1987-07-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200048171-A1 ORGANIC COMPOUND, ORGANIC LIGHT-EMITTING ELEMENT, DISPLAY DEVICE, IMAGING DEVICE, ELECTRONIC DEVICE, ILLUMINATION DEVICE, AND MOVING OBJECT OCIAD1, L1CAM, SPIN4 GAA 3284/4885CTBP2 3673/4885POLB 4314/4885
US-20150126502-A1 INHIBITORS OF POLO-LIKE KINASE POLK, PLK1, POLR2E GAA 712/4885CTBP2 4702/4885POLB 9/4885
US-20020103400-A1 Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same MAP2K5, MAP2K4, MAP2K1 GAA 1236/4885CTBP2 4715/4885POLB 789/4885
US-11370733-B2 Organic compound, organic light-emitting element, display device, imaging device, electronic device, illumination device, and moving object OCIAD1, L1CAM, SPIN4 GAA 3284/4885CTBP2 3673/4885POLB 4314/4885
US-20220081378-A1 ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE CCNL2, ORC3, OR51E2 GAA 3990/4885CTBP2 1972/4885POLB 2651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.