Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 11/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13671802 | 0.81 | PRKCQ (0.58) | PRKCQ | |
| SCHEMBL13720151 | 0.81 | PRKCQ (0.68) | PRKCQ | |
| SCHEMBL3816212 | 0.74 | PDE2A (0.40) | AURKARPS6KB1PDE2APRKCQRAB9A | |
| SCHEMBL4475220 | 0.74 | PDE2A (0.40) | AURKARPS6KB1PDE2ARAB9ANPC1 | |
| SCHEMBL16586038 | 0.73 | PRKCQ (0.64) | PRKCQMAPT | |
| SCHEMBL3320228 | 0.73 | AURKA (0.49) | AURKARPS6KB1PDE2ARAB9ANPC1 | |
| SCHEMBL17741867 | 0.72 | PDE2A (0.48) | AURKARPS6KB1PDE2ARAB9ANPC1 | |
| SCHEMBL5161423 | 0.71 | PRKCQ (0.48) | PRKCQMAPT | |
| SCHEMBL21704230 | 0.71 | AURKA (0.47) | AURKARPS6KB1PDE2ARAB9ANPC1 | |
| SCHEMBL654089 | 0.67 | SYK (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765791-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006014482-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |