Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20731189 | 0.86 | CLK4 (0.44) | DYRK1AMAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL23938083 | 0.85 | RAB9A (0.46) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL20731188 | 0.85 | PDE2A (0.47) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL23938082 | 0.80 | CXCR4 (0.56) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL3320228 | 0.75 | AURKA (0.49) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL5648300 | 0.74 | CLK4 (0.47) | RAB9ANPC1DYRK1AMAPT | |
| SCHEMBL17741867 | 0.73 | PDE2A (0.48) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL18539279 | 0.73 | RAB9A (0.53) | AURKARPS6KB1RAB9ANPC1POLB | |
| SCHEMBL24730682 | 0.71 | VNN1 (0.53) | RAB9ANPC1POLBHDAC3HDAC1 | |
| SCHEMBL5164069 | 0.71 | AURKA (0.43) | AURKARPS6KB1RAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |