SCHEMBL5164527

SCHEMBL5164527

CCC(CC)C1C(=O)NC(C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OXTR P30559 20/20 1.00
AVPR2 P30518 2/20 0.87

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5432398 1.00 OXTR (1.00) OXTRAVPR2
Epelsiban SCHEMBL1597672 0.93 OXTR (1.00) OXTRAVPR2
Epelsiban SCHEMBL29384587 0.93 OXTR (1.00) OXTRAVPR2
Epelsiban SCHEMBL6849956 0.93 OXTR (1.00) OXTRAVPR2
Epelsiban SCHEMBL29703890 0.93 OXTR (1.00) OXTRAVPR2
Epelsiban SCHEMBL19641424 0.93 OXTR (1.00) OXTRAVPR2
SCHEMBL13824336 0.90 OXTR (0.81) OXTRAVPR2
Epelsiban SCHEMBL1598655 0.88 OXTR (0.89) OXTRAVPR2
Epelsiban SCHEMBL14889946 0.87 OXTR (0.88) OXTRAVPR2
SCHEMBL5429926 0.87 OXTR (0.83) OXTRAVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1768974-A1 SUBSTITUTED DIKETOPIPERAZINES AS OXYTOCIN ANTAGONISTS GLAXO GROUP LIMITED (GB) 2007-04-04 EP disclosed
WO-2006000759-A1 SUBSTITUTED DIKETOPIPERAZINES AS OXYTOCIN ANTAGONISTS GLAXO GROUP LIMITED (GB) 2006-01-05 WO disclosed