Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | YWHAG | P61981 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165395 | 0.89 | MEN1 (0.43) | MEN1KMT2ASMN1; SMN2MAP3K5MAPT | |
| SCHEMBL5163582 | 0.85 | MEN1 (0.49) | MEN1KMT2AMAP3K5MAPTL3MBTL1 | |
| SCHEMBL5166395 | 0.78 | TP53 (0.47) | MEN1KMT2ASMN1; SMN2MAP3K5PGR | |
| SCHEMBL19114839 | 0.78 | TP53 (0.49) | MEN1KMT2ASMN1; SMN2MAP3K5MAPT | |
| SCHEMBL5180583 | 0.77 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2MAP3K5MAPT | |
| SCHEMBL15190559 | 0.76 | MEN1 (0.51) | MEN1KMT2AMAP3K5MAPTL3MBTL1 | |
| SCHEMBL5164257 | 0.75 | MEN1 (0.50) | MEN1KMT2AMAP3K5MAPTL3MBTL1 | |
| Paquinimod SCHEMBL1573633 | 0.75 | MEN1 (0.50) | MEN1KMT2AMAP3K5MAPTL3MBTL1 | |
| Paquinimod SCHEMBL29362498 | 0.75 | MEN1 (0.50) | MEN1KMT2AMAP3K5MAPTL3MBTL1 | |
| SCHEMBL19114836 | 0.75 | TP53 (0.51) | MEN1KMT2ASMN1; SMN2MAP3K5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224172-B1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |