Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | AHCY | P23526 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21752762 | 0.87 | DPP4 (0.56) | KDM1ATGFBR1OPRD1AHCYDPP4 | |
| SCHEMBL4663275 | 0.82 | TGFBR1 (0.54) | KDM1ATGFBR1OPRD1DPP4HCRTR2 | |
| SCHEMBL21714047 | 0.82 | KDM1A (0.47) | KDM1AOPRD1STSAHCYDPP4 | |
| SCHEMBL29819176 | 0.82 | KDM1A (0.47) | KDM1AOPRD1STSAHCYDPP4 | |
| SCHEMBL5163011 | 0.79 | TGFBR1 (0.56) | KDM1ATGFBR1 | |
| SCHEMBL21664373 | 0.78 | KDM1A (0.49) | KDM1AOPRD1DPP4PRMT5HCRTR2 | |
| SCHEMBL21713659 | 0.78 | KDM1A (0.47) | KDM1AOPRD1AHCYPRMT5APP | |
| SCHEMBL29819318 | 0.78 | KDM1A (0.47) | KDM1AOPRD1AHCYPRMT5APP | |
| SCHEMBL17393885 | 0.76 | ATM (0.58) | KDM1ATGFBR1OPRD1STSDPP4 | |
| SCHEMBL17393887 | 0.76 | ATM (0.58) | KDM1ATGFBR1OPRD1STSDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | KDM1A 609/4885TGFBR1 4394/4885OPRD1 3889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.