SCHEMBL5164919

SCHEMBL5164919

C=CC(=O)OCCC[Si](C)(CCCOC(=O)C=C)OC

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.57
ALDH1A1 P00352 4/20 0.57
CYP3A4 P08684 2/20 0.57
HPGD P15428 1/20 0.56
TP53 P04637 3/20 0.47
HIF1A Q16665 3/20 0.47
HSD17B10 Q99714 1/20 0.47
THRB P10828 2/20 0.40
ATM Q13315 1/20 0.37
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HCAR2 Q8TDS4 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16536835 0.94 TSHR (0.59) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16538025 0.92 TSHR (0.56) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16537699 0.89 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16536948 0.88 TSHR (0.56) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16537667 0.87 TSHR (0.55) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL712918 0.86 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL80818 0.86 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL81411 0.86 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL16537513 0.85 TSHR (0.58) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL20573003 0.84 TSHR (0.55) TSHRALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1211278-B1 Organic - inorganic composite particles and production process thereof NIPPON CATALYTIC CHEM IND (JP) 2007-03-21 EP disclosed
EP-0653663-B1 Organic-inorganic composite particles and production process therefor NIPPON CATALYTIC CHEM IND (JP) 2002-09-18 EP disclosed
EP-1211278-A2 Organic - inorganic composite particles and production process thereof NIPPON SHOKUBAI CO., LTD. (JP) 2002-06-05 EP disclosed
US-5700874-A CONJUGATED DIENE/VINYLAROMATIC HYDROCARBON COPOLYMER MODIFIED WITH ALKOXYSILANE BRIDGESTONE CORPORATION (JP) 1997-12-23 US disclosed
US-5670257-A HYDROLYZING AND CONDENSING ORGANOSILICON COMPOUND; HEAT TREATMENT; SPACERS FOR LIQUID CRYSTAL DISPLAY; NONFRACTURING NIPPON SHOKUBAI CO., LTD. (JP) 1997-09-23 US disclosed
US-5580619-A LIQUID CRYSTAL DISPLAY NIPPON SHOKUBAI CO., LTD. (JP) 1996-12-03 US disclosed
US-5503932-A SPACERS FOR LIQUID CRYSTAL DISPLAYS REQUIRING UNIFORM GAP DISTANCE BETWEEN MEMBERS; RESILIENCE NIPPON SHOKUBAI CO., LTD. (JP) 1996-04-02 US disclosed
EP-0653663-A1 Organic-inorganic composite particles and production process therefor NIPPON SHOKUBAI CO., LTD. (JP) 1995-05-17 EP disclosed