Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167825 | 0.90 | PTPN1 (0.38) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5188715 | 0.90 | PTPN1 (0.36) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5167003 | 0.88 | PTPN5 (0.45) | PTPN1PTPN5ACLYNR1H2NR1H3 | |
| SCHEMBL5892093 | 0.86 | PTPN1 (0.37) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5163875 | 0.84 | NR1H2 (0.32) | PTPN1ACLYPTGER2NR1H2NR1H3 | |
| SCHEMBL5891975 | 0.84 | PTPN1 (0.37) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5891989 | 0.83 | PTPN1 (0.37) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5891853 | 0.83 | PTPN1 (0.39) | PTPN1PTPN5ACLYPTGER2NR1H2 | |
| SCHEMBL5163868 | 0.81 | NR1H2 (0.35) | PTPN1ACLYPTGER2NR1H2NR1H3 | |
| SCHEMBL5165795 | 0.81 | ACLY (0.33) | PTPN1ACLYPTGER2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | PTPN1 2/4885PTPN5 11/4885ACLY 3966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.