SCHEMBL516629

SCHEMBL516629

O=C(Cl)Oc1ccc(C2(c3ccc(OC(=O)Cl)cc3)c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.49
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
KDM4E B2RXH2 1/20 0.49
LMNA P02545 1/20 0.49
OPRK1 P41145 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
POLB P06746 1/20 0.44
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
PDK2 Q15119 4/20 0.38
THRB P10828 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
HIF1A Q16665 1/20 0.35
APEX1 P27695 1/20 0.34
NPC1 O15118 1/20 0.34
MAPK1 P28482 1/20 0.34
RAB9A P51151 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11940933 0.83 MAPT (0.62) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL1116239 0.82 PDK2 (0.46) PDK2THRBTDP1
SCHEMBL23919629 0.81 KMT2A (0.54) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL811884 0.81 KMT2A (0.46) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL17050289 0.81 KMT2A (0.46) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL30390881 0.81 KMT2A (0.46) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL4853061 0.80 MAPT (0.45) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL479174 0.78 ELANE (0.54) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL21405710 0.78 KMT2A (0.60) MAPTKMT2AMEN1KDM4ELMNA
SCHEMBL13671582 0.78 MAPT (0.57) MAPTKMT2AMEN1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120029116-A1 CURABLE ADHESIVE COMPOSITIONS, PROCESS, AND APPLICATIONS TRILLION SCIENCE, INC. (US) 2012-02-02 US disclosed
US-8084553-B2 Curable adhesive compositions, process, and applications TRILLION SCIENCE, INC. (US) 2011-12-27 US disclosed
US-20090181165-A1 Curable adhesive compositions, Process, and applications TRILLION SCIENCE, INC. (US) 2009-07-16 US disclosed
WO-2009089314-A1 CURABLE ADHESIVE COMPOSITIONS, PROCESS, AND APPLICATIONS TRILLION SCIENCE, INC. (US) 2009-07-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029116-A1 CURABLE ADHESIVE COMPOSITIONS, PROCESS, AND APPLICATIONS RBX1, SUZ12, CDH1 MAPT 547/4885KMT2A 955/4885MEN1 4614/4885
US-20090181165-A1 Curable adhesive compositions, Process, and applications RBX1, SUZ12, CDH1 MAPT 547/4885KMT2A 955/4885MEN1 4614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.