SCHEMBL5166376

SCHEMBL5166376

Oc1ccc2c(c1)N=CCO2

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.45
CYP3A4 P08684 1/20 0.44
ESR1 P03372 4/20 0.37
ESR2 Q92731 4/20 0.37
TRPA1 O75762 1/20 0.34
MAPT P10636 3/20 0.33
RAB9A P51151 2/20 0.33
ALDH1A1 P00352 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
ENPP2 Q13822 1/20 0.31
NPC1 O15118 1/20 0.31
MAPK1 P28482 1/20 0.31
CALM1 P0DP23 1/20 0.30
TTR P02766 1/20 0.30
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30513578 1.00 SYK (0.45) SYKCYP3A4ESR1ESR2TRPA1
SCHEMBL21464696 0.85 ESR1 (0.47) SYKCYP3A4ESR1ESR2TRPA1
SCHEMBL657838 0.78 MAPT (0.40) SYKMAPTRAB9AALDH1A1MAOA
SCHEMBL7937313 0.77 MAPT (0.43) SYKCYP3A4MAPTRAB9AALDH1A1
SCHEMBL29712933 0.77 BLM (0.40) SYKCYP3A4MAPTMAOB
Hydrochloric Acid SCHEMBL28791571 0.74 ALDH1A1 (0.49) SYKMAPTRAB9AALDH1A1NPC1
SCHEMBL12319727 0.73 PARP1 (0.40) SYKTRPA1MAPTRAB9AALDH1A1
SCHEMBL31017007 0.73 ALDH1A1 (0.41) CYP3A4TRPA1MAPTRAB9AALDH1A1
SCHEMBL30933579 0.73 MAPT (0.33) SYKMAPTRAB9AALDH1A1MAOB
SCHEMBL6239222 0.73 ALDH1A1 (0.49) SYKRAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858796-B2 Oxidative hair dye WELLA AG (DE) 2007-04-11 EP claimed
EP-0684035-B1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine OREAL (FR) 1996-09-11 EP claimed
EP-0684035-A1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine L'OREAL (FR) 1995-11-29 EP claimed
JP-7316030-A None JP disclosed
WO-2025099111-A1 NEW TELESCOPING SYNTHESES OF 6-HYDROXY-BENZOMORPHOLINE (3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL) WELLA GERMANY GMBH (DE) 2025-05-15 WO disclosed
CN-111989082-B Catalytic dye system ELC 管理有限责任公司 2023-10-31 CN disclosed
CN-111971017-B Method for forming catalytic dye system ELC 管理有限责任公司 2023-07-28 CN disclosed
EP-3773426-B1 METHOD FOR FORMING A CATALYZED DYE SYSTEM ELC MAN LLC (US) 2023-03-01 EP disclosed
US-11369554-B2 Catalyzed dye system ELC MANAGEMENT LLC (US) 2022-06-28 US disclosed
US-11160738-B2 Method for forming a catalyzed dye system ELC MANAGEMENT LLC (US) 2021-11-02 US disclosed
EP-3826605-A1 CATALYZED DYE SYSTEM ELC Management LLC (US) 2021-06-02 EP disclosed
EP-0858796-A2 Oxidative hair dye Wella Aktiengesellschaft (DE) 1998-08-19 EP disclosed
US-5690695-A Composition for the oxidation dyeing of keratinous fibres, comprising a para-phenylenediamine derivative and a 6-hydroxy-1, 4-benzomorpholine and dyeing process using such a composition L'OREAL (FR) 1997-11-25 US disclosed
EP-0684035-B1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine OREAL (FR) 1996-09-11 EP disclosed
EP-0684035-B1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine OREAL (FR) 1996-09-11 EP disclosed
EP-0705598-A1 Oxidation dye composition for keratinic fibers comprising an association of at least two paraphenylenediamine derivatives, and their use L'OREAL (FR) 1996-04-10 EP disclosed
JP-H07316030-A COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBERS, CONTAINING PARAPHENYLENEDIAMINE DERIVATIVE AND 6-HYDROXY-1,4-BENZOXAZINE, AND PROCESS USING THE SAME L'OREAL SA 1995-12-05 JP disclosed
EP-0684035-A1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine L'OREAL (FR) 1995-11-29 EP disclosed
EP-0684035-A1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine L'OREAL (FR) 1995-11-29 EP disclosed
EP-0684035-A1 Keratineous fibres oxidation dyeing composition containing a derivative of paraphenylenediamine and a 6-hydroxy 1,4-benzoxazine L'OREAL (FR) 1995-11-29 EP disclosed