Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.41 |
| ▸ | TOP1 | P11387 | 9/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5276465 | 0.92 | P2RX7 (0.40) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL12917322 | 0.90 | TOP1 (0.47) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL964967 | 0.90 | TOP1 (0.47) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL5242516 | 0.89 | KDM4E (0.51) | KCNH2POLBKDM4EALDH1A1TDP1 | |
| SCHEMBL5284756 | 0.88 | KDM4E (0.41) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL12917323 | 0.84 | TOP1 (0.45) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL4252792 | 0.83 | TOP1 (0.46) | TOP1KCNH2POLBKDM4EALDH1A1 | |
| SCHEMBL12917330 | 0.82 | TOP1 (0.45) | P2RX7TOP1KCNH2POLBKDM4E | |
| SCHEMBL5283636 | 0.82 | POLB (0.43) | P2RX7KCNH2POLBKDM4EALDH1A1 | |
| SCHEMBL5182149 | 0.82 | TOP1 (0.39) | P2RX7TOP1KCNH2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768973-B1 | SUBSTITUTED QUINOLONES | AICURIS GMBH & CO KG (DE) | 2007-12-05 | — | — | EP | disclosed |
| EP-1768973-A1 | SUBSTITUTED QUINOLONES | AiCuris GmbH & Co. KG (DE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006008046-A1 | SUBSTITUTED QUINOLONES | AICURIS GMBH & CO. KG (DE) | 2006-01-26 | — | — | WO | disclosed |