Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22814982 | 0.88 | ALDH1A1 (0.68) | MAPTKMT2AALDH1A1MEN1TDP1 | |
| SCHEMBL22814979 | 0.88 | ALDH1A1 (0.68) | MAPTKMT2AALDH1A1MEN1TDP1 | |
| SCHEMBL33261 | 0.87 | AKR1C3 (0.64) | MAPTKMT2AALDH1A1MEN1TDP1 | |
| SCHEMBL22542070 | 0.86 | ALDH1A1 (0.69) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL19187554 | 0.86 | TDP1 (0.73) | MAPTKMT2AALDH1A1MEN1TDP1 | |
| SCHEMBL14320635 | 0.85 | TDP1 (0.55) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL3098998 | 0.84 | MAPT (0.57) | MAPTKMT2AALDH1A1MEN1TDP1 | |
| SCHEMBL27363823 | 0.84 | TDP1 (0.61) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL14320485 | 0.83 | TDP1 (0.56) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL12082863 | 0.83 | MAPT (0.50) | NPC1RAB9AMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768959-A2 | HETERO ISONIPECOTIC MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-04 | — | — | EP | claimed |
| WO-2006004793-A2 | HETERO ISONIPECOTIC MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2006-01-12 | — | — | WO | claimed |